Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat1tm1Ruch mutation
(0 available);
any
Nmnat1 mutation
(34 available)
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normal phenotype
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• mice are viable and fertile, show no retinal degeneration and normal retinal function, and mice subjected to strong white light for 4 hours show unaffected retinal morphology 2 weeks after exposure to the light damage
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat1tm1d(EUCOMM)Wtsi mutation
(0 available);
any
Nmnat1 mutation
(34 available)
Nmnat1tm1Ruch mutation
(0 available);
any
Nmnat1 mutation
(34 available)
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vision/eye
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• marker analysis shows loss of both rod and cone photoreceptor outer segments in 12 month old mice
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• by 12 months of age, about 40% of photoreceptors are degenerated
• mice subjected to strong white light for 4 hours show marked photoreceptor degeneration 2 weeks after exposure to light damage
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• retinal degeneration in the outer nuclear layer is seen at 5 months of age
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• ERG on dark-adapted mice under scotopic conditions shows a reduction in the amplitudes of rod-generated a-waves starting at 5 months of age which becomes more pronounced with increasing age
• mice subjected to strong white light for 4 hours show a reduction in scotopic a-wave (rod cells) responses in light-damaged retinas
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• mice subjected to strong white light for 4 hours show a reduction in b-wave (bipolar cells) responses in light-damaged retinas
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nervous system
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• marker analysis shows loss of both rod and cone photoreceptor outer segments in 12 month old mice
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• by 12 months of age, about 40% of photoreceptors are degenerated
• mice subjected to strong white light for 4 hours show marked photoreceptor degeneration 2 weeks after exposure to light damage
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cellular
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• marker analysis indicates that light-induced retinal damage triggers ER stress
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