Analysis Tools
normal phenotype
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• tamoxifen-treated adult mice appear phenotypically normal with no significant weight loss relative to control mice
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Allele Symbol Allele Name Allele ID |
Rnpc3tm1c(EUCOMM)Wtsi targeted mutation 1c, Wellcome Trust Sanger Institute MGI:6269405 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tamoxifen-treated adult mice appear phenotypically normal with no significant weight loss relative to control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 8 days after tamoxifen (TAM) treatment, adult mice show signs of malnutrition and stress (scruffy coat, docile, and hunched behavior) requiring euthanasia
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• adult mice show irreversible weight loss by 6 days after TAM treatment
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• hunched behavior at 8 days after TAM treatment
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• infiltration of immune cells in small intestinal epithelium at 6 days after TAM treatment
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• signs of erosive esophagitis at 8 days after TAM treatment
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• significant reduction in thymus weight at 8 days at 8 days after TAM treatment
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• significantly smaller thymus with no discernible medullary or cortical regions at 8 days after TAM treatment
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• at 8 days after TAM treatment
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• at 8 days after TAM treatment
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• significant leucopenia at 8 days after TAM treatment
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• significant decrease in lymphocyte number at 8 days after TAM treatment
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• significant decrease in monocyte number at 8 days after TAM treatment
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• significant increase in the number of apoptotic cells in the highly proliferative, stem/progenitor compartment of the small intestinal crypts at 2 and 4 days after TAM treatment
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• reduced cell proliferation in the proliferative compartment of the small intestinal epithelium at 4 days after TAM treatment
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• marked reduction in BrdU+ cells in small intestinal crypts at 4 days after TAM treatment
• new BrdU+ crypt-like structures corresponding to sites of regeneration at 6 and 8 days after TAM treatment
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• severe atrophy of the entire gastrointestinal epithelium with mucosa disruption from the esophagus to the rectum at 8 days after TAM treatment
• extensive degeneration of the epithelial layer interspersed with discrete pockets of regenerating crypt-like structures
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• disrupted organization of the squamous epithelium of the esophagus at 8 days after TAM treatment
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• at 8 days after TAM treatment, the epithelial monolayer lining the small intestine and colon contains vacuolated epithelial cells scattered throughout the submucosa; epithelial layer degeneration is intermixed with discrete pockets of regenerating crypt-like structures
• loss of epithelial integrity in the small intestine and colon with nuclei rounding up and cells losing apico-basal polarity at 4 days after TAM treatment
• highly disorganized small intestine epithelium, with crypt loss, decreased villus height, infiltration of immune cells, and ulceration at 6 days after TAM treatment
• thinner and flatter epithelial cells in the colon at 6 days after TAM treatment
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• at 8 days after TAM treatment
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• loss of crypt structure in the colon at 4 days after TAM treatment
• large vacuolated spaces in colonic crypts at 6 days after TAM treatment
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• loss of crypt structure in the small intestine at 4 days after TAM treatment
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• reduced villus height in the small intestine at 6 days after TAM treatment
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• degeneration of columnar mucous epithelium of the glandular stomach at 8 days after TAM treatment
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• infiltration of immune cells in small intestinal epithelium at 6 days after TAM treatment
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• signs of erosive esophagitis at 8 days after TAM treatment
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• significant reduction in thymus weight at 8 days at 8 days after TAM treatment
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• significantly smaller thymus with no discernible medullary or cortical regions at 8 days after TAM treatment
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• at 8 days after TAM treatment
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• at 8 days after TAM treatment
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• significant decrease in RBC number at 8 days after TAM treatment
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• severe thrombocytopenia at 8 days after TAM treatment
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• significant leucopenia at 8 days after TAM treatment
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• significant decrease in lymphocyte number at 8 days after TAM treatment
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• significant decrease in monocyte number at 8 days after TAM treatment
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• paucity of sebaceous glands at 8 days after TAM treatment
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• scruffy coat at 8 days at 8 days after TAM treatment
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• mild skin abnormalities at 8 days after TAM treatment
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• attenuated epidermis at 8 days after TAM treatment
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• loss of crypt structure in the colon at 4 days after TAM treatment
• large vacuolated spaces in colonic crypts at 6 days after TAM treatment
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• loss of crypt structure in the small intestine at 4 days after TAM treatment
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• significant reduction in thymus weight at 8 days at 8 days after TAM treatment
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• significantly smaller thymus with no discernible medullary or cortical regions at 8 days after TAM treatment
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• at 8 days after TAM treatment
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• at 8 days after TAM treatment
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• paucity of sebaceous glands at 8 days after TAM treatment
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• significant increase in the number of apoptotic cells in the highly proliferative, stem/progenitor compartment of the small intestinal crypts at 2 and 4 days after TAM treatment
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• reduced cell proliferation in the proliferative compartment of the small intestinal epithelium at 4 days after TAM treatment
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• marked reduction in BrdU+ cells in small intestinal crypts at 4 days after TAM treatment
• new BrdU+ crypt-like structures corresponding to sites of regeneration at 6 and 8 days after TAM treatment
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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