Phenotypes associated with this allele

• Allele Symbol: Acsl6^tm1.1Jeme
• Allele Name: targeted mutation 1.1, Jessica M Ellis
• Allele ID: MGI:6268795
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acsl6^tm1.1Jeme/Acsl6^tm1.1Jeme	involves: BALB/cJ * C57BL/6	MGI:6269168

Genotype
MGI:6269168

hm1

• Allelic Composition: Acsl6^tm1.1Jeme/Acsl6^tm1.1Jeme
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:267563 )

N • neuromuscular grip strength

N • open field test performance

decreased startle reflex ( J:267563 )

• trend toward reduction in response to electrical impulse to footpad and significantly reduced in response to acoustic stimuli

impaired coordination ( J:267563 )

• poor performance in wire hang test

• trend toward reduced performance at rotarod test at age 12 months

growth/size/body

growth/size/body region phenotype ( J:267563 )

N • body length and weight

N • brain width, length and weight

hematopoietic system

abnormal microglial cell activation ( J:267563 )

• after i.p. lipopolysaccharide (LPS) injection

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:267563 )

N • food intake

abnormal amino acid metabolism ( J:267563 )

• altered hippocampal tryptophan, glutathione, methionine, and cysteine levels

abnormal carbohydrate metabolism ( J:267563 )

• altered hippocampal lactate, glucose-6-phosphate, phosphoenolpyruvate, fumarate, and pantothenate levels

abnormal lipogenesis ( J:267563 )

• decreased omega-3 docosahexaenoic acid (DHA) levels in brain

• increased omega-6 Arachidonate-containing phospholipids level in brain

• lipid levels in liver and soleus muscle

• 40% decreased Acyl-CoA synthetase (ACS) in brain

decreased lipogenesis ( J:267563 )

• decreased omega-3 docosahexaenoic acid (DHA) levels in brain

• 40% decreased Acyl-CoA synthetase (ACS) in brain

increased lipogenesis ( J:267563 )

• increased omega-6 Arachidonate-containing phospholipids level in brain

abnormal nucleotide metabolism ( J:267563 )

• altered hippocampal cytosine, uracil and CDP levels

immune system

abnormal microglial cell activation ( J:267563 )

• after i.p. lipopolysaccharide (LPS) injection

nervous system

abnormal microglial cell activation ( J:267563 )

• after i.p. lipopolysaccharide (LPS) injection