Phenotypes associated with this allele

• Allele Symbol: Thoc7^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6260024
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thoc7^em1(IMPC)J/Thoc7^em1(IMPC)J	C57BL/6NJ-Thoc7^em1(IMPC)J/Mmjax	MGI:6480609
ht2	Thoc7^em1(IMPC)J/Thoc7^+	C57BL/6NJ-Thoc7^em1(IMPC)J/Mmjax	MGI:7317078

Genotype
MGI:6480609

hm1

• Allelic Composition: Thoc7^em1(IMPC)J/Thoc7^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Thoc7^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Thoc7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Thoc7^em1(IMPC)J/Thoc7^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts grown in vitro hatch from the zona pellucida and form irregular outgrowths.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• although blastocysts are recovered at expected Mendelian ratios at E3.5, no homozygous embryos can be recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro, blastocysts do hatch from the zona pellucida but form irregular outgrowths after 3 days in culture

Genotype
MGI:7317078

ht2

• Allelic Composition: Thoc7^em1(IMPC)J/Thoc7⁺
• Genetic Background: C57BL/6NJ-Thoc7^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Thoc7

hematopoietic system

increased mean corpuscular hemoglobin concentration ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - JAX