Phenotypes associated with this allele

• Allele Symbol: Stk35^tm1Kll
• Allele Name: targeted mutation 1, Kate L Loveland
• Allele ID: MGI:6257038
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk35^tm1Kll/Stk35^tm1Kll	B6.Cg-Stk35^tm1Kll	MGI:6257056

Genotype
MGI:6257056

hm1

• Allelic Composition: Stk35^tm1Kll/Stk35^tm1Kll
• Genetic Background: B6.Cg-Stk35^tm1Kll

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:264258 )

• several mice die between E12.5 and E13.5

reproductive system

decreased male germ cell number ( J:264258 )

decreased mature ovarian follicle number ( J:264258 )

small ovary ( J:264258 )

abnormal seminiferous tubule epithelium morphology ( J:264258 )

• germinal epithelium vacuolization

abnormal Sertoli cell morphology ( J:264258 )

• cells slough off into the tubule lumen

small testis ( J:264258 )

decreased testis weight ( J:264258 )

decreased litter size ( J:264258 )

• when males are mated to female mice

vision/eye

abnormal eye morphology ( J:264258 )

abnormal anterior eye segment morphology ( J:264258 )

• goniodysgenesis

• a failure of anterior chamber formation

abnormal iridocorneal angle ( J:264258 )

aniridia ( J:264258 )

anterior iris synechia ( J:264258 )

cornea opacity ( J:264258 )

abnormal lens morphology ( J:264258 )

microphthalmia ( J:264258 )

abnormal retina morphology ( J:264258 )

retina detachment ( J:264258 )

vitreous body deposition ( J:264258 )

• proliferative pigmented masses

embryo

abnormal embryonic tissue morphology ( J:264258 )

• developmental defects at E12.5 and E13.5

cellular

decreased male germ cell number ( J:264258 )

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:264258 )

small ovary ( J:264258 )

abnormal seminiferous tubule epithelium morphology ( J:264258 )

• germinal epithelium vacuolization

abnormal Sertoli cell morphology ( J:264258 )

• cells slough off into the tubule lumen

small testis ( J:264258 )

decreased testis weight ( J:264258 )