Phenotypes associated with this allele

• Allele Symbol: Washc5^tm1.2Cbee
• Allele Name: targeted mutation 1.2, Christian Beetz
• Allele ID: MGI:6256428
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Washc5^tm1.2Cbee/Washc5^tm1.2Cbee	involves: C57BL/6	MGI:6256430
ht2	Washc5^tm1.2Cbee/Washc5^+	involves: C57BL/6	MGI:6256431

Genotype
MGI:6256430

hm1

• Allelic Composition: Washc5^tm1.2Cbee/Washc5^tm1.2Cbee
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:266630 )

• no embryos are detected at E13.5 and no signs of terminated embryonic development in uteri suggesting lethality in very early embryonic stages

Genotype
MGI:6256431

ht2

• Allelic Composition: Washc5^tm1.2Cbee/Washc5⁺
• Genetic Background: involves: C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:266630 )

N • foot-base angles do not differ from wild-type

cellular

cellular phenotype ( J:266630 )

N • mouse adult fibroblasts grown in culture show unaltered endosomal tabulation and integrity of organelle compartments

growth/size/body

growth/size/body region phenotype ( J:266630 )

N • mice exhibit normal body weight

nervous system

nervous system phenotype ( J:266630 )

N • cortical neurons grown in culture do not exhibit any abnormalities, showing normal axon length and number of axonal branches

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	hereditary spastic paraplegia 8	DOID:0110823	OMIM:603563	J:266630