All Phenotypes Cd4<em1Litt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd4^em1Litt
endonuclease-mediated mutation 1, Dan R Littman
MGI:6220669

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd4^em1Litt/Cd4^em1Litt	involves: C57BL/6J	MGI:7439996
cx2	Cd4^em1Litt/Cd4^em1Litt Rr386^em1Pdi/Rr386^em1Pdi	involves: C57BL/6J	MGI:7439995

Allelic Composition	Cd4^em1Litt/Cd4^em1Litt
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^em1Litt mutation (1 available); any Cd4 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:333574 )

N	• normal reaction to Leishmania major (L. major) infection

Allelic Composition	Cd4^em1Litt/Cd4^em1Litt Rr386^em1Pdi/Rr386^em1Pdi
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^em1Litt mutation (1 available); any Cd4 mutation (82 available)
Rr386^em1Pdi mutation (0 available); any Rr386 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T helper 1 cell number ( J:333574 )

• lower frequency and number of Tbet+ CD11a-hi CD44+ helper T cells in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)

abnormal lymphocyte activation involved in immune response ( J:333574 )

• delayed swelling of cutaneous infection point after infection with Leishmania major (L. major)

• increased parasitic burden 28 and 54 days after infection with Leishmania major (L. major)

• Leishmania major (L. major) infection lesions resolved in normal time

• normal parasitic burden 9 days after infection with Leishmania major (L. major)

immune system

immune system phenotype ( J:333574 )

N

• normal proportions of CD11a-hi CD49d+ and CD11a-hi CD44+ T cells in draining lymph nodes (dLNs) 9 days after infection with Leishmania major (L. major)

• normal frequency of GATA3+ CD11a-hi CD44+ T cells in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)

• normal absolute T cell numbers in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)

decreased T helper 1 cell number ( J:333574 )

• lower frequency and number of Tbet+ CD11a-hi CD44+ helper T cells in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)

abnormal lymphocyte activation involved in immune response ( J:333574 )

• delayed swelling of cutaneous infection point after infection with Leishmania major (L. major)

• increased parasitic burden 28 and 54 days after infection with Leishmania major (L. major)

• Leishmania major (L. major) infection lesions resolved in normal time

• normal parasitic burden 9 days after infection with Leishmania major (L. major)

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