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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Emc3tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6200599
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi
Sftpctm1(cre/ERT2,rtTA)Hap/Sftpc+ 		involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N MGI:8405105
cn2
 		Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi
Sftpctm1.1Xft/Sftpctm1(cre/ERT2,rtTA)Hap 		involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N MGI:8405107


Genotype
MGI:8405105
cn1
Allelic
Composition		 Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi
Sftpctm1(cre/ERT2,rtTA)Hap/Sftpc+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emc3tm1c(EUCOMM)Wtsi mutation (0 available); any Emc3 mutation (16 available)
Sftpctm1(cre/ERT2,rtTA)Hap mutation (0 available); any Sftpc mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:376785 )
N
• lung morphology is not altered in tamoxifen-treated mice




Genotype
MGI:8405107
cn2
Allelic
Composition		 Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi
Sftpctm1.1Xft/Sftpctm1(cre/ERT2,rtTA)Hap
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emc3tm1c(EUCOMM)Wtsi mutation (0 available); any Emc3 mutation (16 available)
Sftpctm1.1Xft mutation (0 available); any Sftpc mutation (27 available)
Sftpctm1(cre/ERT2,rtTA)Hap mutation (0 available); any Sftpc mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:376785 )
N
• tamoxifen-treated adult mice show restoration of the decreased maximal respiration capacity of alveolar 2 epithelial cells cell mitochondria and improved glycolytic capacity that is seen in single mutant Sftpc mice
enlarged alveolar lamellar bodies ( J:376785 )
• tamoxifen-treated mice show enlarged lamellar body morphology in alveolar 2 epithelial cells

respiratory system
respiratory system phenotype ( J:376785 )
N
• tamoxifen-treated mice show restoration of the lung morphology seen in single mutant Sftpc mice, with rescue of the alveolar simplification in neonatal mice and in adult tamoxifen-treated mice
enlarged alveolar lamellar bodies ( J:376785 )
• tamoxifen-treated mice show enlarged lamellar body morphology in alveolar 2 epithelial cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/08/2026
MGI 6.24 		The Jackson Laboratory