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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mlh1m2Btlr
mutation 2, Bruce Beutler
MGI:6200239
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mlh1m2Btlr/Mlh1m2Btlr C57BL/6J-Mlh1m2Btlr MGI:6200241


Genotype
MGI:6200241
hm1
Allelic
Composition		 Mlh1m2Btlr/Mlh1m2Btlr
Genetic
Background		 C57BL/6J-Mlh1m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1m2Btlr mutation (0 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgE level ( J:265207 )
• total IgE in the serum
increased IgM level ( J:265207 )
• diminished T-dependent antibody responses to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

immune system
abnormal humoral immune response ( J:265207 )
• diminished T-dependent antibody responses to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgE level ( J:265207 )
• total IgE in the serum
increased IgM level ( J:265207 )
• diminished T-dependent antibody responses to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory