Phenotypes associated with this allele

• Allele Symbol: Tnip1^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:6200058
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnip1^m1Btlr/Tnip1^m1Btlr	C57BL/6J-Tnip1^m1Btlr	MGI:6200060

Genotype
MGI:6200060

hm1

• Allelic Composition: Tnip1^m1Btlr/Tnip1^m1Btlr
• Genetic Background: C57BL/6J-Tnip1^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:265175 )

• mice show susceptibility to dextran sodium sulfate-induced colitis at 7 and 10 days post-DSS treatment

increased dendritic cell number ( J:265175 )

increased B-1a cell number ( J:265175 )

increased B-1b cell number ( J:265175 )

decreased B cell number ( J:265175 )

• of B cells and IgM+ B cells in the peripheral blood

decreased B-2 B cell number ( J:265175 )

increased macrophage cell number ( J:265175 )

increased IgA level ( J:265175 )

• in response to ovalbumin/alum administration

increased IgE level ( J:265175 )

• of total IgE and the level of OVA-specific IgE after OVA/alum administration

increased anti-double stranded DNA antibody level ( J:265175 )

digestive/alimentary system

increased susceptibility to induced colitis ( J:265175 )

• mice show susceptibility to dextran sodium sulfate-induced colitis at 7 and 10 days post-DSS treatment

hematopoietic system

increased dendritic cell number ( J:265175 )

increased B-1a cell number ( J:265175 )

increased B-1b cell number ( J:265175 )

decreased B cell number ( J:265175 )

• of B cells and IgM+ B cells in the peripheral blood

decreased B-2 B cell number ( J:265175 )

increased macrophage cell number ( J:265175 )

increased IgA level ( J:265175 )

• in response to ovalbumin/alum administration

increased IgE level ( J:265175 )

• of total IgE and the level of OVA-specific IgE after OVA/alum administration