All Phenotypes Tg(CAG-MYC,-GFP*)#Rugg MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Eif2ak3^tm1.2Drc/Eif2ak3^tm1.2Drc Pten^tm1Hwu/Pten^tm1Hwu Tg(CAG-MYC,-GFP*)#Rugg/0 Tg(Pbsn-cre)4Prb/0	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2	MGI:6198768
cn2	Pten^tm1Hwu/Pten^tm1Hwu Tg(CAG-MYC,-GFP*)#Rugg/0 Tg(Pbsn-cre)4Prb/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2	MGI:6198766
cn3	Tg(CAG-MYC,-GFP*)#Rugg/0 Tg(Pbsn-cre)4Prb/0	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:6198765

Allelic Composition	Eif2ak3^tm1.2Drc/Eif2ak3^tm1.2Drc Pten^tm1Hwu/Pten^tm1Hwu Tg(CAG-MYC,-GFP*)#Rugg/0 Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak3^tm1.2Drc mutation (1 available); any Eif2ak3 mutation (51 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(CAG-MYC,-GFP*)#Rugg mutation (0 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased prostate gland tumor incidence ( J:261540 )

• mice show reduced prostate growth, with a decrease prostate cancer progression and cell proliferation compared to Pten^tm1Hwu/Pten^tm1Hwu Tg(Pbsn-cre)4Prb/0 Tg(CAG-MYC,-GFP)#Rugg/0 mice

neoplasm

decreased prostate gland tumor incidence ( J:261540 )

• mice show reduced prostate growth, with a decrease prostate cancer progression and cell proliferation compared to Pten^tm1Hwu/Pten^tm1Hwu Tg(Pbsn-cre)4Prb/0 Tg(CAG-MYC,-GFP)#Rugg/0 mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:261540 )

• mice show decreased overall survival, with a mean life span of 75 weeks

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:261540 )

• mice develop prostatic adenocarcinoma by 10 weeks of age

• mice with developed tumors treated with a small-molecule inhibitor of P-eIF2alpha activity, ISRIB, show tumor regression within 3 weeks of treatment, with no signs of toxicity

increased prostate intraepithelial neoplasia incidence ( J:261540 )

• mice show enlargement of prostate growth by 6 weeks of age and accelerated development of high-grade prostatic intraepithelial neoplasia compared to single conditional Pten^tm1Hwu mutants

neoplasm

increased prostate gland adenocarcinoma incidence ( J:261540 )

• mice develop prostatic adenocarcinoma by 10 weeks of age

• mice with developed tumors treated with a small-molecule inhibitor of P-eIF2alpha activity, ISRIB, show tumor regression within 3 weeks of treatment, with no signs of toxicity

increased prostate intraepithelial neoplasia incidence ( J:261540 )

• mice show enlargement of prostate growth by 6 weeks of age and accelerated development of high-grade prostatic intraepithelial neoplasia compared to single conditional Pten^tm1Hwu mutants

reproductive system

increased prostate gland adenocarcinoma incidence ( J:261540 )

• mice develop prostatic adenocarcinoma by 10 weeks of age

• mice with developed tumors treated with a small-molecule inhibitor of P-eIF2alpha activity, ISRIB, show tumor regression within 3 weeks of treatment, with no signs of toxicity

increased prostate intraepithelial neoplasia incidence ( J:261540 )

• mice show enlargement of prostate growth by 6 weeks of age and accelerated development of high-grade prostatic intraepithelial neoplasia compared to single conditional Pten^tm1Hwu mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:261540

Allelic Composition	Tg(CAG-MYC,-GFP*)#Rugg/0 Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-MYC,-GFP*)#Rugg mutation (0 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:261540 )

• mice exhibit increased proliferation in the prostate epithelium but do not develop adenocarcinoma by 1 year of age

neoplasm

neoplasm ( J:261540 )

N	• mice do not develop prostate gland adenocarcinoma by 1 year of age

reproductive system

abnormal prostate gland morphology ( J:261540 )

• mice exhibit increased proliferation in the prostate epithelium but do not develop adenocarcinoma by 1 year of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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