Analysis Tools
adipose tissue
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• an increase in the number of large lipid droplets is seen in mice on a high-sucrose diet
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homeostasis/metabolism
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• mice exhibit a 2- to 3-fold increase in hepatic triglyceride content after 4 weeks on a high-sucrose diet, however on a high-fat diet, the increase in triglyceride levels is similar to controls
• however, levels of triglycerides, phosphatidylcholine, cholesteryl esters and free cholesterol in the livers of females fed a chow diet are normal and mice fed a high-fat diet exhibit a similar level to insulin resistance and glucose tolerance as controls
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liver/biliary system
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• mice exhibit a 2- to 3-fold increase in hepatic triglyceride content after 4 weeks on a high-sucrose diet, however on a high-fat diet, the increase in triglyceride levels is similar to controls
• however, levels of triglycerides, phosphatidylcholine, cholesteryl esters and free cholesterol in the livers of females fed a chow diet are normal and mice fed a high-fat diet exhibit a similar level to insulin resistance and glucose tolerance as controls
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• mice develop fatty liver when fed a high-sucrose or high-fat diet
• however, no changes in circulating liver enzymes are seen in high-sucrose fed mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| metabolic dysfunction-associated steatotic liver disease | DOID:0080208 |
OMIM:613282 OMIM:613387 |
J:264475 | |
