All Phenotypes Maz<em#Mhll> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Maz^em#Mhll
endonuclease-mediated mutation, Meade Haller
MGI:6197212

Summary

2 genotypes

Allelic Composition	Maz^em#Mhll/Maz^em#Mhll
Genetic Background	C57BL/6J-Maz^em#Mhll

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maz^em#Mhll mutation (0 available); any Maz mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• fewer than expected mice are present at E16.5 and E18.5

• further lethality is observed by P13

reproductive system

male infertility ( J:257647 )

• in the surviving male mouse despite normal testis and epididymal morphology

renal/urinary system

renal hypoplasia ( J:257647 )

• in the surviving mouse

absent kidney ( J:257647 )

• in some mice

single kidney ( J:257647 )

• in the surviving male mouse despite normal ureter development

cardiovascular system

abnormal heart atrium morphology ( J:257647 )

• mismatched atrial size in the surviving male mouse despite normal heart size

• however, no obstructions are observed

growth/size/body

fetal growth retardation ( J:257647 )

• slight

Allelic Composition	Maz^em#Mhll/Maz⁺
Genetic Background	C57BL/6J-Maz^em#Mhll

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maz^em#Mhll mutation (0 available); any Maz mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• fewer than expected mice are present at E16.5 and E18.5

renal/urinary system

urinary bladder hypoplasia ( J:257647 )

• modestly with altered architecture

abnormal bladder urine volume ( J:257647 )

• following methylene blue dye injection, mice exhibit abrogated bladder capacity compared with wild-type mice

• however, the mouse did not exhibit increased VUR, cryptochisim or overt penile malformation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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