About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gsdmdem4Fcw
endonuclease-mediated mutation 4, Fengchao Wang
MGI:6196334
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gsdmdem4Fcw/Gsdmdem4Fcw C57BL/6N-Gsdmdem4Fcw/J MGI:6196336


Genotype
MGI:6196336
hm1
Allelic
Composition		 Gsdmdem4Fcw/Gsdmdem4Fcw
Genetic
Background		 C57BL/6N-Gsdmdem4Fcw/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdmdem4Fcw mutation (1 available); any Gsdmd mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage apoptosis ( J:101977 )
• resist LPS-induced pyroptosis in bone marrow-derived macrophages
abnormal susceptibility to bacterial infection ( J:101977 )
• exposure to Clostridium difficile toxin B or LPS fails to induce pyrotosis

cellular
abnormal macrophage apoptosis ( J:101977 )
• resist LPS-induced pyroptosis in bone marrow-derived macrophages

hematopoietic system
abnormal macrophage apoptosis ( J:101977 )
• resist LPS-induced pyroptosis in bone marrow-derived macrophages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory