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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gsdmdem4Fcw
endonuclease-mediated mutation 4, Fengchao Wang
MGI:6196334
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gsdmdem4Fcw/Gsdmdem4Fcw C57BL/6N-Gsdmdem4Fcw/J MGI:6196336


Genotype
MGI:6196336
hm1
Allelic
Composition		 Gsdmdem4Fcw/Gsdmdem4Fcw
Genetic
Background		 C57BL/6N-Gsdmdem4Fcw/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdmdem4Fcw mutation (1 available); any Gsdmd mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage apoptosis ( J:101977 )
• resist LPS-induced pyroptosis in bone marrow-derived macrophages
abnormal susceptibility to bacterial infection ( J:101977 )
• exposure to Clostridium difficile toxin B or LPS fails to induce pyrotosis

cellular
abnormal macrophage apoptosis ( J:101977 )
• resist LPS-induced pyroptosis in bone marrow-derived macrophages

hematopoietic system
abnormal macrophage apoptosis ( J:101977 )
• resist LPS-induced pyroptosis in bone marrow-derived macrophages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory