All Phenotypes Abcc6<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Abcc6^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6195711

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/?	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}	MGI:6241503
cn2	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/? Tg(Cdx1-cre)23Kem/?	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn} Tg(Cdx1-cre)23Kem	MGI:6241505
cn3	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Cdh16-cre)91Igr/?	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Cdh16-cre)91Igr	MGI:6241512
cn4	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Cdh5-cre)7Mlia/?	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Cdh5-cre)7Mlia	MGI:6241514
cn5	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(CMV-cre)1Cgn/?	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(CMV-cre)1Cgn	MGI:6241496
cn6	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Fabp4-cre)1Rev/?	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Fabp4-cre)1Rev	MGI:6241516
cn7	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Pdgfrb-cre)35Vli/?	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Pdgfrb-cre)35Vli	MGI:6241519
cn8	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her/?	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her	MGI:6241522
cn9	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} E2f1^{Tg(Wnt1-cre)2Sor}/?	B6.Cg-E2f1^{Tg(Wnt1-cre)2Sor} Abcc6^{tm1c(EUCOMM)Wtsi}	MGI:6241498
cn10	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} E2f1^{Tg(Wnt1-cre)2Sor}/? Speer6-ps1^{Tg(Alb-cre)21Mgn}/?	B6.Cg-E2f1^{Tg(Wnt1-cre)2Sor} Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}	MGI:6241501
cn11	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Pax7^tm1(cre)Mrc/?	B6.Cg-Pax7^tm1(cre)Mrc Abcc6^{tm1c(EUCOMM)Wtsi}	MGI:6241508
cn12	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Ptprc^tm1(cre)Medv/?	B6.Cg-Ptprc^tm1(cre)Medv Abcc6^{tm1c(EUCOMM)Wtsi}	MGI:6241510

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/?
Genetic Background	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

calcinosis ( J:252837 )

integument

abnormal snout skin morphology ( J:252837 )

calcified skin ( J:252837 )

• calcification of the fibrous capsule surrounding the muzzle vibrissae is not observed at 20 weeks of age, however, at one year of age, some calcification is present

growth/size/body

abnormal snout skin morphology ( J:252837 )

craniofacial

abnormal snout skin morphology ( J:252837 )

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/? Tg(Cdx1-cre)23Kem/?
Genetic Background	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn} Tg(Cdx1-cre)23Kem

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

calcinosis ( J:252837 )

integument

abnormal snout skin morphology ( J:252837 )

calcified skin ( J:252837 )

• calcification of the fibrous capsule surrounding the muzzle vibrissae is not observed at 20 weeks of age, however, at one year of age, some calcification is present

growth/size/body

abnormal snout skin morphology ( J:252837 )

craniofacial

abnormal snout skin morphology ( J:252837 )

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Cdh16-cre)91Igr/?
Genetic Background	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Cdh16-cre)91Igr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Tg(Cdh16-cre)91Igr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:252837 )

N	• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Cdh5-cre)7Mlia/?
Genetic Background	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Cdh5-cre)7Mlia

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:252837 )

N	• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(CMV-cre)1Cgn/?
Genetic Background	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(CMV-cre)1Cgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Tg(CMV-cre)1Cgn mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

calcinosis ( J:252837 )

integument

abnormal snout skin morphology ( J:252837 )

calcified skin ( J:252837 )

• calcification of the fibrous capsule surrounding the muzzle vibrissae occurs at 20 weeks of age

growth/size/body

abnormal snout skin morphology ( J:252837 )

craniofacial

abnormal snout skin morphology ( J:252837 )

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Fabp4-cre)1Rev/?
Genetic Background	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Fabp4-cre)1Rev

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Tg(Fabp4-cre)1Rev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:252837 )

N	• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Pdgfrb-cre)35Vli/?
Genetic Background	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Pdgfrb-cre)35Vli

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Tg(Pdgfrb-cre)35Vli mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:252837 )

N	• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her/?
Genetic Background	B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Tg(Tagln-cre)1Her mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:252837 )

N	• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} E2f1^{Tg(Wnt1-cre)2Sor}/?
Genetic Background	B6.Cg-E2f1^{Tg(Wnt1-cre)2Sor} Abcc6^{tm1c(EUCOMM)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
E2f1^{Tg(Wnt1-cre)2Sor} mutation (2 available); any E2f1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

calcinosis ( J:252837 )

integument

abnormal snout skin morphology ( J:252837 )

calcified skin ( J:252837 )

• 1 out of 22 mice exhibit mild calcification of the fibrous capsule surrounding the muzzle vibrissae occurs at 20 weeks of age

• at one year of age, the calcification phenotype shows reduced penetrance and variable expression

growth/size/body

abnormal snout skin morphology ( J:252837 )

craniofacial

abnormal snout skin morphology ( J:252837 )

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} E2f1^{Tg(Wnt1-cre)2Sor}/? Speer6-ps1^{Tg(Alb-cre)21Mgn}/?
Genetic Background	B6.Cg-E2f1^{Tg(Wnt1-cre)2Sor} Abcc6^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

calcinosis ( J:252837 )

integument

abnormal snout skin morphology ( J:252837 )

calcified skin ( J:252837 )

• 5 out of 13 mice exhibit calcification of the fibrous capsule surrounding the muzzle vibrissae occurs at 20 weeks of age

growth/size/body

abnormal snout skin morphology ( J:252837 )

craniofacial

abnormal snout skin morphology ( J:252837 )

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Pax7^tm1(cre)Mrc/?
Genetic Background	B6.Cg-Pax7^tm1(cre)Mrc Abcc6^{tm1c(EUCOMM)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:252837 )

N	• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Ptprc^tm1(cre)Medv/?
Genetic Background	B6.Cg-Ptprc^tm1(cre)Medv Abcc6^{tm1c(EUCOMM)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Ptprc^tm1(cre)Medv mutation (0 available); any Ptprc mutation (188 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:252837 )

N	• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

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