Phenotypes associated with this allele

• Allele Symbol: Bcas3^tm1.1Msin
• Allele Name: targeted mutation 1.1, Maneesha S Inamdar
• Allele ID: MGI:6195663
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcas3^tm1.1Msin/Bcas3^tm1.1Msin	involves: BALB/cJ * C57BL/6NCrlj * CBA/JNCrlj	MGI:6195770

Genotype
MGI:6195770

hm1

• Allelic Composition: Bcas3^tm1.1Msin/Bcas3^tm1.1Msin
• Genetic Background: involves: BALB/cJ * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:262744 )

• no mice are present by E11.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:262744 )

• fewer than expected mice are present at E8.5

cardiovascular system

abnormal blood vessel endothelium morphology ( J:262744 )

• disorganized

abnormal vascular endothelial cell morphology ( J:262744 )

• impaired or random migration and are unable to form organized vessels

abnormal capillary morphology ( J:262744 )

• fewer capillaries

abnormal intersomitic vessel morphology ( J:262744 )

• discontinuous intersomitic vessels

abnormal vascular development ( J:262744 )

abnormal dorsal aorta morphology ( J:262744 )

• unpatterned at E8.5

• discontinuous with reduced lumen

abnormal vascular branching morphogenesis ( J:262744 )

• impaired branching in head and heart vasculature

decreased angiogenesis ( J:262744 )

• reduced sprouting in head and heart vasculature

disorganized yolk sac vascular plexus ( J:262744 )

abnormal heart morphology ( J:262744 )

abnormal coronary vessel morphology ( J:262744 )

• at E9.5

abnormal endocardium morphology ( J:262744 )

• reduced development

atrioventricular septal defect ( J:262744 )

• fused atrioventricular canal

small heart ( J:262744 )

• collapsed, small heart chambers

embryo

embryonic growth retardation ( J:262744 )

• at E9.5

delayed somite formation ( J:262744 )

• reduced number of somites at E9.5

abnormal placenta morphology ( J:262744 )

• fetal vessels fail to invade into the developing placenta

abnormal chorionic plate morphology ( J:262744 )

• composed of mostly trophoblast giant cells

decreased placental labyrinth size ( J:262744 )

• lacking stratified layers

abnormal visceral yolk sac morphology ( J:262744 )

• few major blood vessels with irregular and fused vessels

• congested capillaries are lined by thinner endothelium

disorganized yolk sac vascular plexus ( J:262744 )

pale yolk sac ( J:262744 )

growth/size/body

embryonic growth retardation ( J:262744 )

• at E9.5

abnormal head morphology ( J:262744 )

• disorganized with reduced capillaries and impaired branching of intersomitic vessels at E9.5

cellular

decreased cell migration ( J:262744 )

• cell derived from the yolk sac exhibit reduced migration rates and loss of directionality