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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem119em1(cre/ERT2)Gfng
endonuclease-mediated mutation 1, Guoping Feng
MGI:6195002
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cgasem2Nki/Cgas+
Tmem119em1(cre/ERT2)Gfng/Tmem119+ 		involves: C57BL/6J * C57BL/6NTac MGI:7539423


Genotype
MGI:7539423
cn1
Allelic
Composition		 Cgasem2Nki/Cgas+
Tmem119em1(cre/ERT2)Gfng/Tmem119+
Genetic
Background		 involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cgasem2Nki mutation (0 available); any Cgas mutation (26 available)
Tmem119em1(cre/ERT2)Gfng mutation (1 available); any Tmem119 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired spatial learning ( J:340265 )
• impaired cognitive performance in Morris water maze test after tamoxifen-mediated induction

nervous system
loss of hippocampal neurons ( J:340265 )
• lower hippocampal neuron density test after tamoxifen-mediated induction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory