Analysis Tools
homeostasis/metabolism
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• mitochondria exhibit reduced levels of trimethyllysine (TML) and asymmetric dimethylarginine (ADMA) along with a decrease in saccharopine, an intermediate in lysine degradation, indicating impaired mitochondrial import of methylated amino acids
• fasted mice show a depletion of hepatic guanidinoacetate, a mitochondrial intermediate of arginine metabolism and creatine biosynthesis
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