Slc25a45^em1Brsy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc25a45^em1Brsy
• Name: solute carrier family 25, member 45; endonuclease-mediated mutation 1, Kivanc Birsoy
• MGI ID: MGI:8262722
• Gene: Slc25a45 Location: Chr19:5927828-5935796 bp, + strand Genetic Position: Chr19, 4.34 cM
• Alliance: Slc25a45^em1Brsy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using gRNA 5-GCTGTACACTCCGAACAGGACGG-3 targeting exon 4 generated a knock-out allele. (J:374674)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a45 Mutation: 24 strains or lines available

References

• Original: J:374674 Khan A, et al., Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis. Cell Metab. 2025 Nov 4;37(11):2220-2232.e8
• All: 1 reference(s)