Phenotypes associated with this allele

• Allele Symbol: Tg(RHO*P347S)A1Tili
• Allele Name: transgene insertion A1, Tiansen Li
• Allele ID: MGI:6187993
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ntrk3^tm1.1Tes/Ntrk3^+ Tg(RHO*P347S)A1Tili/0	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:6188005
cx2	Ntrk3^tm1.1Tes/Ntrk3^tm1.1Tes Tg(RHO*P347S)A1Tili/0	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:6188007
cx3	Rho^tm1Jlem/Rho^tm1Jlem Tg(RHO*P347S)A1Tili/0	involves: 129S4/SvJae * FVB/N	MGI:6378570
tg4	Tg(RHO*P347S)A1Tili/0	involves: C57BL/6J * FVB/N	MGI:6188004

Genotype
MGI:6188005

cx1

• Allelic Composition: Ntrk3^tm1.1Tes/Ntrk3⁺; Tg(RHO*P347S)A1Tili/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

thin retina outer nuclear layer ( J:262975 )

• as early as P18 to a lesser degree than in Tg(RHO*P347S)#Tili mice until P28

• however, mice exhibit normal nerve fiber, ganglion cell and inner plexiform layer thickness

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:262975

Genotype
MGI:6188007

cx2

• Allelic Composition: Ntrk3^tm1.1Tes/Ntrk3^tm1.1Tes; Tg(RHO*P347S)A1Tili/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

reproductive system

decreased litter size ( J:262975 )

vision/eye

abnormal eye morphology ( J:262975 )

• some mice do not open their eye lids normally compared with wild-type mice

microphthalmia ( J:262975 )

• some mice do not open their eye lids normally compared with wild-type mice

growth/size/body

decreased body weight ( J:262975 )

• low-weight offspring

Genotype
MGI:6378570

cx3

• Allelic Composition: Rho^tm1Jlem/Rho^tm1Jlem; Tg(RHO*P347S)A1Tili/0
• Genetic Background: involves: 129S4/SvJae * FVB/N

vision/eye

short photoreceptor outer segment ( J:280289 )

• mice exhibit a shortened outer segment at 4 weeks of age

retina outer nuclear layer degeneration ( J:280289 )

• the outer nuclear layer begins to degenerate at 4 weeks of age and is completely degenerated by 24 weeks of age

retina degeneration ( J:280289 )

• severe retinal degeneration at 1 month of age

abnormal a-wave shape ( J:280289 )

• 15-fold reduction in a- waves at 4 weeks of age and complete loss of a-waves at 12 weeks of age

• gene therapy with a microRNA sequence that specifically silences the pathogenic human rhodopsin gene and replacement with a rhodopsin that is resistant to this microRNA at P19 results in rescue of visual function

absent b-wave ( J:280289 )

• 3-fold reduction in b-waves at 4 weeks of age and complete loss of b-waves at 12 weeks of age

nervous system

short photoreceptor outer segment ( J:280289 )

• mice exhibit a shortened outer segment at 4 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:280289

Genotype
MGI:6188004

tg4

• Allelic Composition: Tg(RHO*P347S)A1Tili/0
• Genetic Background: involves: C57BL/6J * FVB/N

vision/eye

thin retina outer nuclear layer ( J:262975 )

• as early as P18

• however, mice exhibit normal nerve fiber, ganglion cell and inner plexiform layer thickness

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:262975