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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mkrn2tm1.1Bhj
targeted mutation 1.1, Bing-Hua Jiang
MGI:6163817
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mkrn2tm1.1Bhj/Mkrn2tm1.1Bhj involves: 129P2/OlaHsd * C57BL/6J MGI:6163819


Genotype
MGI:6163819
hm1
Allelic
Composition		 Mkrn2tm1.1Bhj/Mkrn2tm1.1Bhj
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mkrn2tm1.1Bhj mutation (0 available); any Mkrn2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:250191 )
• both male and female homozygous mice exhibit decreased weight compared to controls

reproductive system
abnormal outer dense fiber morphology ( J:250191 )
• the outer dense fiber is either absent or improperly arranged
abnormal sperm axoneme morphology ( J:250191 )
• complete loss of the axoneme doublets in one side of the fibrous sheath
• disordered assembly of the '9 + 2' arrangement
abnormal acrosome morphology ( J:250191 )
• abnormal or missing acrosomes
absent acrosome ( J:250191 )
• acrosomes are missing in some cases
abnormal spermatid morphology ( J:250191 )
• the number of round spermatids was significantly decreased
decreased male germ cell number ( J:250191 )
• the number of round spermatids was significantly decreased
abnormal ectoplasmic specialization morphology ( J:250191 )
• the ectoplasmic specialization arrangement is disrupted
abnormal spermiation ( J:250191 )
• seminiferous tubules retained elongated spermatids among germ cells and did not release
male infertility ( J:250191 )
• male mice are completely sterile

cellular
abnormal outer dense fiber morphology ( J:250191 )
• the outer dense fiber is either absent or improperly arranged
abnormal sperm axoneme morphology ( J:250191 )
• complete loss of the axoneme doublets in one side of the fibrous sheath
• disordered assembly of the '9 + 2' arrangement
abnormal acrosome morphology ( J:250191 )
• abnormal or missing acrosomes
absent acrosome ( J:250191 )
• acrosomes are missing in some cases
abnormal spermatid morphology ( J:250191 )
• the number of round spermatids was significantly decreased
decreased male germ cell number ( J:250191 )
• the number of round spermatids was significantly decreased

endocrine/exocrine glands
abnormal ectoplasmic specialization morphology ( J:250191 )
• the ectoplasmic specialization arrangement is disrupted




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory