All Phenotypes Adam10<Pied> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adam10^Pied
Pied
MGI:6163474

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr	HRA/SkhKcl-Adam10^Pied Hr^Hr	MGI:6163711
cx2	Adam10^Pied/Adam10⁺ Hr^hr/Hr⁺	HRA/SkhKcl-Adam10^Pied Hr^Hr	MGI:6163712
cx3	Adam10^Pied/Adam10^tm1Psa Hr^hr/Hr^hr	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl	MGI:6163720
cx4	Adam10^Pied/Adam10⁺ Cd44^tm1Hbg/Cd44^tm1Hbg Hr^hr/Hr^hr	involves: 129S1/Sv * 129X1/SvJ * HRA/SkhKcl	MGI:6163716
cx5	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(Dct-lacZ)A12Jkn/0	involves: C3HeB/FeJ * C57BL/6 * CBA * HRA/SkhKcl	MGI:6163724
cx6	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(KRT14-Kitl*)4XTG2Bjl/0	involves: C57BL/6J * HRA/SkhKcl * SJL	MGI:6163714
cx7	Adam10^Pied/Adam10^Pied Hr^hr/Hr^hr	involves: CAST/EiJ * HRA/SkhKcl	MGI:6163718

Allelic Composition	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr
Genetic Background	HRA/SkhKcl-Adam10^Pied Hr^Hr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^Pied mutation (0 available); any Adam10 mutation (37 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

hairless ( J:262499 )

abnormal skin pigmentation ( J:262499 )

• unlike in Hr^Hr homozygotes, 20 week old mice exhibit light brown, freckle-like spots or macules with a striated appearance due to a heavier concentration of melanin at the dermis and epidermis junction

• at 10 months, mice exhibit un-striated macules in the tail, ear and feet that does not change skin color unlike in Hr^Hr homozygotes

pigmentation

abnormal skin pigmentation ( J:262499 )

• at 10 months, mice exhibit un-striated macules in the tail, ear and feet that does not change skin color unlike in Hr^Hr homozygotes

Allelic Composition	Adam10^Pied/Adam10⁺ Hr^hr/Hr⁺
Genetic Background	HRA/SkhKcl-Adam10^Pied Hr^Hr

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:262499 )

N	• no macules are observed in trunk hair

Allelic Composition	Adam10^Pied/Adam10^tm1Psa Hr^hr/Hr^hr
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^Pied mutation (0 available); any Adam10 mutation (37 available)
Adam10^tm1Psa mutation (0 available); any Adam10 mutation (37 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small pharyngeal arch ( J:262499 )

• at E9.5

caudal body truncation ( J:262499 )

• at E9.5

decreased embryo size ( J:262499 )

• at E9.5

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

abnormal somite border morphology ( J:262499 )

• not delineated at E9.5

cardiovascular system

abnormal heart looping ( J:262499 )

• linear at E9.5

enlarged pericardium ( J:262499 )

• at E9.5

nervous system

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

telencephalon hypoplasia ( J:262499 )

• at E9.5

growth/size/body

decreased embryo size ( J:262499 )

• at E9.5

craniofacial

small pharyngeal arch ( J:262499 )

• at E9.5

Allelic Composition	Adam10^Pied/Adam10⁺ Cd44^tm1Hbg/Cd44^tm1Hbg Hr^hr/Hr^hr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * HRA/SkhKcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^Pied mutation (0 available); any Adam10 mutation (37 available)
Cd44^tm1Hbg mutation (4 available); any Cd44 mutation (67 available)
Hr^hr mutation (17 available); any Hr mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

hairless ( J:262499 )

abnormal skin pigmentation ( J:262499 )

• trunk and tail macules at 10 months

pigmentation

abnormal skin pigmentation ( J:262499 )

• trunk and tail macules at 10 months

Allelic Composition	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(Dct-lacZ)A12Jkn/0
Genetic Background	involves: C3HeB/FeJ * C57BL/6 * CBA * HRA/SkhKcl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanocyte morphology ( J:262499 )

• groups of melanocytes are observed at 3 months unlike in Hr^Hr homozygotes

• at 5 months, mice exhibit large groups of melanocytes with melanin deposition in the epidermis unlike Hr^Hr homozygotes

increased melanocyte number ( J:262499 )

• in the skin

integument

hairless ( J:262499 )

Allelic Composition	Adam10^Pied/Adam10⁺ Hr^hr/Hr^hr Tg(KRT14-Kitl*)4XTG2Bjl/0
Genetic Background	involves: C57BL/6J * HRA/SkhKcl * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

hairless ( J:262499 )

abnormal skin pigmentation ( J:262499 )

• at 5 months, mice exhibit the same degree of light trunk pigmentation as in Tg(KRT14-Kitl*)4XTG2Bjl mice

pigmentation

abnormal skin pigmentation ( J:262499 )

• at 5 months, mice exhibit the same degree of light trunk pigmentation as in Tg(KRT14-Kitl*)4XTG2Bjl mice

Allelic Composition	Adam10^Pied/Adam10^Pied Hr^hr/Hr^hr
Genetic Background	involves: CAST/EiJ * HRA/SkhKcl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:262499 )

• no mice are present at weaning

embryo

small pharyngeal arch ( J:262499 )

• at E9.5

caudal body truncation ( J:262499 )

• at E9.5

decreased embryo size ( J:262499 )

• at E9.5

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

abnormal somite border morphology ( J:262499 )

• not delineated at E9.5

cardiovascular system

abnormal heart looping ( J:262499 )

• linear at E9.5

enlarged pericardium ( J:262499 )

• at E9.5

nervous system

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

telencephalon hypoplasia ( J:262499 )

• at E9.5

growth/size/body

decreased embryo size ( J:262499 )

• at E9.5

craniofacial

small pharyngeal arch ( J:262499 )

• at E9.5

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