Phenotypes associated with this allele

• Allele Symbol: Ecel1^em2Hiki
• Allele Name: endonuclease-mediated mutation 2, Hiroshi Kiyama
• Allele ID: MGI:6160056
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ecel1^em2Hiki/Ecel1^em2Hiki Tg(Hlxb9-GFP)1Tmj/0	involves: C57BL/6 * CBA	MGI:6160086

Genotype
MGI:6160086

cx1

• Allelic Composition: Ecel1^em2Hiki/Ecel1^em2Hiki; Tg(Hlxb9-GFP)1Tmj/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:260240 )

respiratory system

respiratory failure ( J:260240 )

nervous system

abnormal axon guidance ( J:260240 )

• at E11.5, the abducens nerves stop extending their axons towards the target muscles around the eye is some mutants

• at E12.5, substantial numbers of abducens nerves follow the wrong pathway in some mutants and some stop extending their axons toward their target muscles without any correct innervation indicating axon guidance defects

• however, the oculomotor nerves and trochlear nerves show a normal trajectory to target muscles

abnormal innervation pattern to muscle ( J:260240 )

• embryonic motor nerves show abnormal innervation to hindlimb muscles

• the number of motor nerve terminals is decreased in gracilis anterior muscles and rectus femoris muscle

• mice show axonal arborization defects in foot muscles

abnormal motor neuron innervation pattern ( J:260240 )

• embryonic motor nerves show abnormal innervation to hindlimb muscles and defects in axonal arborization in foot muscles

abnormal phrenic nerve innervation pattern to diaphragm ( J:260240 )

• mice exhibit impaired axonal arborization of motor nerves in the diaphragm

abnormal abducens nerve morphology ( J:260240 )

• reduction in nerve length of abducens nerves

cellular

abnormal axon guidance ( J:260240 )

• at E11.5, the abducens nerves stop extending their axons towards the target muscles around the eye is some mutants

• at E12.5, substantial numbers of abducens nerves follow the wrong pathway in some mutants and some stop extending their axons toward their target muscles without any correct innervation indicating axon guidance defects

• however, the oculomotor nerves and trochlear nerves show a normal trajectory to target muscles