All Phenotypes Map2k1<tm2.1Chrn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map2k1^tm2.1Chrn
targeted mutation 2.1, M Jean Charron
MGI:6157680

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2k1^tm2.1Chrn/Map2k1^tm2.1Chrn	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	MGI:6159581
ht2	Map2k1^tm2.1Chrn/Map2k1⁺	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	MGI:6159580
ht3	Map2k1^tm2.1Chrn/Map2k1^tm1.1Chrn	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	MGI:6159582

Allelic Composition	Map2k1^tm2.1Chrn/Map2k1^tm2.1Chrn
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm2.1Chrn mutation (1 available); any Map2k1 mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pulmonary artery stenosis ( J:261678 )

• pulmonary artery stenosis is observed at E13.5

• left and right pulmonary artery lumen areas are reduced

craniofacial

increased cranium length ( J:261678 )

nervous system

increased astrocyte number ( J:261678 )

• increased density of GFAP+ astrocytes is found in sensory cortices and hippocampal CA1

increased oligodendrocyte number ( J:261678 )

• increased density of oligodendrocytes in the sensory cortex

skeleton

increased cranium length ( J:261678 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cardiofaciocutaneous syndrome		DOID:0060233	OMIM:PS115150	J:261678

Allelic Composition	Map2k1^tm2.1Chrn/Map2k1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm2.1Chrn mutation (1 available); any Map2k1 mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pulmonary artery stenosis ( J:261678 )

• pulmonary artery stenosis is observed at E13.5 left

• left and right pulmonary artery lumen areas are reduced

Allelic Composition	Map2k1^tm2.1Chrn/Map2k1^tm1.1Chrn
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm1.1Chrn mutation (0 available); any Map2k1 mutation (92 available)
Map2k1^tm2.1Chrn mutation (1 available); any Map2k1 mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pulmonary artery stenosis ( J:261678 )

• pulmonary artery stenosis is observed at E13.5

• left and right pulmonary artery lumen areas are reduced

craniofacial

decreased cranium length ( J:261678 )

decreased cranium width ( J:261678 )

skeleton

decreased cranium length ( J:261678 )

decreased cranium width ( J:261678 )

vision/eye

increased inner canthal distance ( J:261678 )

• width of the inner canthal distance is increased

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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