Analysis Tools
cardiovascular system
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• by E9.5, most homozygous embryos exhibit an abnormal heart shape
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craniofacial
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• at E8.5, over half of homozygous embryos have an abnormal head shape; by E9.5, most exhibit abnormally shaped heads
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digestive/alimentary system
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• when the notochord is absent at E8.5, the gut tube is abnormally proximal to the neural tube
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embryo
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• at E9.5, placentas are properly developed and comparable to those in control littermates
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IMPC - JAX
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• by E9.5, most homozygous embryos exhibit failure of turning
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• by E9.5, all homozygous embryos are easily distinguishable from their control littermates
• however, homozygous embryos are normal at E7.5
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• at E8.5 and E9.5, all homozygous embryos lack a properly patterned ventral neural tube, as indicated by the absence of FOXA2 in the floorplate
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• at E8.5 and E9.5, all homozygous embryos show absence of FOXA2 in the floorplate
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• by E9.5, most homozygous embryos exhibit a laterally splayed and open cranial neural tube
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• by E9.5, most homozygous embryos show a kinked caudal neural tube
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• at E8.5, the notochord is absent in some portions of the embryo
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growth/size/body
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• at E8.5, over half of homozygous embryos have an abnormal head shape; by E9.5, most exhibit abnormally shaped heads
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homeostasis/metabolism
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• by E9.5, the heart is often edematous
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mortality/aging
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IMPC - JAX
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IMPC - JAX
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• homozygous embryos are present in Mendelian ratios at E7.5-E9.5 but absent at E12.5
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nervous system
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• at E8.5 and E9.5, all homozygous embryos lack a properly patterned ventral neural tube, as indicated by the absence of FOXA2 in the floorplate
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• at E8.5 and E9.5, all homozygous embryos show absence of FOXA2 in the floorplate
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• by E9.5, most homozygous embryos exhibit a laterally splayed and open cranial neural tube
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• by E9.5, most homozygous embryos show a kinked caudal neural tube
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