Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm2.1Ecan mutation
(0 available);
any
Notch2 mutation
(97 available)
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skeleton
N |
• microarchitecture of the distal femur is normal at 1 month of age, with no differences in cancellous bone volume or cortical thickness compared to wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Notch2tm2.1Ecan mutation
(0 available);
any
Notch2 mutation
(97 available)
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skeleton
N |
• femoral microarchitecture is normal at 1 and 4 months of age and bone marrow-derived macrophage cultures form a similar number of osteoclasts in vitro as controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Notch2tm2.1Ecan mutation
(0 available);
any
Notch2 mutation
(97 available)
|
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skeleton
N |
• femoral microarchitecture is normal at 1 and 4 months of age and bone marrow-derived macrophage cultures form a similar number of osteoclasts in vitro as controls
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm2.1Ecan mutation
(0 available);
any
Notch2 mutation
(97 available)
Tg(BGLAP-cre)1Clem mutation
(1 available)
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skeleton
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• distal femurs exhibit an increase in osteoclast numbers
• however, the number of osteoblasts and bone formation rates are not different from controls
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• distal femurs exhibit an increase in eroded surface
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• cancellous and cortical bone osteopenia is seen in females, but not males, at 1 month of age
• a modest cortical osteopenia with cortical thinning and increased porosity is seen in both males and females at 4 months of age
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• cortical bone porosity is increased in females at 1 and 4 months of age and in males at 4 months of age
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• females exhibit decreased cortical bone volume in the femoral midshaft at 1 and 4 months of age, while males show a decrease at 4 months of age
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• cortical bone area is decreased in 1 month old females
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• cortical bone thickness is decreased in females at 1 and 4 months of age and in males at 4 months of age
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• females exhibit decreased trabecular bone volume in the distal femur at 1 and 4 months of age, with 1 month old females showing an approximate 50% reduction in cancellous bone volume secondary to a reduced number of trabeculae and connectivity density
• at 4 months of age, the skeletal phenotype of females is less pronounced, and cancellous bone volume/total volume is 30% lower than in controls
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• connectivity density is lower and structure model index is higher, indicating a prevalence of rod-like trabeculae over plate-like trabeculae
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• females exhibit decreased trabecular number in the distal femur at 1 and 4 months of age
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• females exhibit increased trabecular separation in the distal femur at 1 and 4 months of age
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• 1 month old females exhibit reduced connectivity density
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• females exhibit decreased trabecular thickness in the distal femur at 4 months of age
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• cortical bone shows suppressed endocortical mineral apposition rate
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hematopoietic system
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• distal femurs exhibit an increase in osteoclast numbers
• however, the number of osteoblasts and bone formation rates are not different from controls
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immune system
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• distal femurs exhibit an increase in osteoclast numbers
• however, the number of osteoblasts and bone formation rates are not different from controls
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limbs/digits/tail
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• distal femurs exhibit an increase in eroded surface
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