Analysis Tools
cardiovascular system
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• by E9.5, nearly all homozygous embryos exhibit abnormal heart morphology
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• by E9.5, nearly all homozygous embryos exhibit enlarged hearts
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craniofacial
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• by E9.5, nearly all homozygous embryos exhibit abnormal branchial arches
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embryo
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• a minority of early E8.5 homozygous embryos are developmentally delayed
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• by E10.5, all homozygous embryos appear grossly abnormal and dying
• however, most are largely normal at E8.5 and all show evidence of all three germ layers at E9.5
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• by E9.5, nearly all homozygous embryos exhibit abnormal branchial arches
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IMPC - JAX
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• at E8.5, an asymmetric anterior neural tube is sometimes observed
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• at E9.5 and E10.5, placentas exhibit multiple labyrinth zone defects
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• at E9.5 and E10.5, the Tfeb+ labyrinth trophoblast layer is markedly reduced
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• chorioallantoic branching is impaired at E9.5 and nearly absent by E10.5, as Gcm1 expression is sparse and remains at the chorioallantoic interface
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growth/size/body
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• by E9.5, nearly all homozygous embryos exhibit enlarged hearts
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• a minority of early E8.5 homozygous embryos are developmentally delayed
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IMPC - JAX
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mortality/aging
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IMPC - JAX
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IMPC - JAX
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• homozygous embryos are present in Mendelian ratios at E8.5 and E9.5; by E10.5, all homozygous embryos show a precipitous decline and are dying
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nervous system
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• at E8.5, an asymmetric anterior neural tube is sometimes observed
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