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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Top2aem2(IMPC)Tcp
endonuclease-mediated mutation 2, The Centre for Phenogenomics
MGI:6157267
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Top2aem2(IMPC)Tcp/Top2aem2(IMPC)Tcp C57BL/6NCrl-Top2aem2(IMPC)Tcp/Tcp MGI:6263742
ht2
 		Top2aem2(IMPC)Tcp/Top2a+ C57BL/6NCrl-Top2aem2(IMPC)Tcp/Tcp MGI:6288793


Genotype
MGI:6263742
hm1
Allelic
Composition		 Top2aem2(IMPC)Tcp/Top2aem2(IMPC)Tcp
Genetic
Background		 C57BL/6NCrl-Top2aem2(IMPC)Tcp/Tcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Top2aem2(IMPC)Tcp mutation (2 available); any Top2a mutation (87 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6288793
ht2
Allelic
Composition		 Top2aem2(IMPC)Tcp/Top2a+
Genetic
Background		 C57BL/6NCrl-Top2aem2(IMPC)Tcp/Tcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Top2aem2(IMPC)Tcp mutation (2 available); any Top2a mutation (87 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
small thymus ( J:211773 )
IMPC - TCP

growth/size/body
enlarged urinary bladder ( J:211773 )
IMPC - TCP

hematopoietic system
small thymus ( J:211773 )
IMPC - TCP
small spleen ( J:211773 )
IMPC - TCP

homeostasis/metabolism

immune system
small thymus ( J:211773 )
IMPC - TCP
small spleen ( J:211773 )
IMPC - TCP

integument

liver/biliary system

renal/urinary system

reproductive system

vision/eye
cornea opacity ( J:211773 )
IMPC - TCP
cataract ( J:211773 )
IMPC - TCP
microphthalmia ( J:211773 )
IMPC - TCP




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory