Phenotypes associated with this allele

• Allele Symbol: Cabp2^tm1Fha
• Allele Name: targeted mutation 1, Francoise Haeseleer
• Allele ID: MGI:6157024
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cabp2^tm1Fha/Cabp2^tm1Fha	involves: C57BL/6J * C57BL/6NTac	MGI:6157322

Genotype
MGI:6157322

hm1

• Allelic Composition: Cabp2^tm1Fha/Cabp2^tm1Fha
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:255928 )

N • thickness of retinal layers

N • morphology of type 6 ON and type 1 OFF retinal bipolar cells and their axons and dendrites

N • number of Ctbp2+ synapses in retina

N • synaptic ribbons and tethered vesicles in IPL and OPL of retina

N • cone bipolar cell and horizontal cell invaginations make normal synapses with cone photoreceptors

abnormal eye electrophysiology ( J:255928 )

• significantly smaller response to 100% contrast light flash in retinal ON alpha ganglion cells

• weaker spike response to 100% contrast step in retinal ON alpha ganglion cells

• significantly smaller difference between maximum and minimum excitatory synaptic current evoked by random noise stimulus in retinal ON alpha ganglion cells

• reduction in amplitude of nonlinearity of excitatory synaptic currents in retinal ON alpha ganglion cells in response to random noise stimulus

• response kinetics and response range to random noise stimulus in retinal OFF T ganglion cells

• time to peak and amplitude of b-waves of electroretinograms in response to light stimulus

nervous system

nervous system phenotype ( J:255928 )

N • thickness of retinal layers

N • morphology of type 6 ON and type 1 OFF retinal bipolar cells and their axons and dendrites

N • number of Ctbp2+ synapses in retina

N • synaptic ribbons and tethered vesicles in IPL and OPL of retina

N • cone bipolar cell and horizontal cell invaginations make normal synapses with cone photoreceptors