Cabp2^tm1Fha
Targeted Allele Detail

Summary

• Symbol: Cabp2^tm1Fha
• Name: calcium binding protein 2; targeted mutation 1, Francoise Haeseleer
• MGI ID: MGI:6157024
• Gene: Cabp2 Location: Chr19:4131578-4137340 bp, + strand Genetic Position: Chr19, 3.79 cM, cytoband A
• Alliance: Cabp2^tm1Fha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255928
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct, containing the tdTomato red fluorescent marker gene and a neomycin resistance gene cassette, was inserted immediately downstream of the ATG translation start site in exon 1. The construct replaces the coding region of exon 1 and exon 2a. Stop codons were introduced in all three reading frames of exon 2b. RT-PCR and immunohistochemistry experiments confirmed the lack of transcript and protein expression in the retina from this allele. (J:255928)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cabp2 Mutation: 24 strains or lines available

References

• Original: J:255928 Sinha R, et al., Lack of CaBP1/Caldendrin or CaBP2 Leads to Altered Ganglion Cell Responses. eNeuro. 2016 Sep-Oct;3(5):ENEURO.0099-16.2016
• All: 2 reference(s)