Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat1tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Nmnat1 mutation
(34 available)
Tg(Crx-cre/ERT2)1Tfur mutation
(1 available)
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nervous system
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• by P28, most photoreceptor cells are degenerated and the outer nuclear layer is absent in the retina
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vision/eye
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• retinal lamination defects are seen at P6
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• by P28, most photoreceptor cells are degenerated and the outer nuclear layer is absent in the retina
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• progressive thinning of the outer nuclear layer
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• reduction in overall retinal thickness is apparent by P15
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat1tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Nmnat1 mutation
(34 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation
(1 available)
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vision/eye
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• mice exhibit reduced thickness of the inner nuclear layer at P9
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• mice exhibit reduced thickness of the outer nuclear layer at P9
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• mice exhibit a reduction of retinal thickness by P15
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• mice exhibit early onset of retinal degeneration by P9-P15
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat1tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Nmnat1 mutation
(34 available)
Tg(Rho-icre)1Ck mutation
(1 available)
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nervous system
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• no rod outer segments are detectable by P15
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• the outer nuclear layer is reduced at P28 but not P7, indicating that most rods are lost
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vision/eye
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• no rod outer segments are detectable by P15
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• the outer nuclear layer is reduced at P28 but not P7, indicating that most rods are lost
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• the outer nuclear layer is reduced at P28 but not P7, indicating that most rods are lost
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Analysis Tools