Phenotypes associated with this allele

• Allele Symbol: Lgr5^{em1(IMPC)Kmpc}
• Allele Name: endonuclease-mediated mutation 1, Korea Mouse Phenotyping Center
• Allele ID: MGI:6156314
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgr5^em1(IMPC)Kmpc/Lgr5^em1(IMPC)Kmpc	C57BL/6NTac-Lgr5^em1(IMPC)Kmpc/Kmpc	MGI:7472085
ht2	Lgr5^em1(IMPC)Kmpc/Lgr5^+	C57BL/6NTac-Lgr5^em1(IMPC)Kmpc/Kmpc	MGI:7472084

Genotype
MGI:7472085

hm1

• Allelic Composition: Lgr5^{em1(IMPC)Kmpc}/Lgr5^{em1(IMPC)Kmpc}
• Genetic Background: C57BL/6NTac-Lgr5^{em1(IMPC)Kmpc}/Kmpc

Data Sources

IMPC Data for Lgr5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

no spontaneous movement ( J:211773 )

IMPC - KMPC

craniofacial

cleft palate ( J:211773 )

IMPC - KMPC

digestive/alimentary system

cleft palate ( J:211773 )

IMPC - KMPC

growth/size/body

cleft palate ( J:211773 )

IMPC - KMPC

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - KMPC

Genotype
MGI:7472084

ht2

• Allelic Composition: Lgr5^{em1(IMPC)Kmpc}/Lgr5⁺
• Genetic Background: C57BL/6NTac-Lgr5^{em1(IMPC)Kmpc}/Kmpc

Data Sources

IMPC Data for Lgr5

behavior/neurological

increased grip strength ( J:211773 )

IMPC - KMPC

no spontaneous movement ( J:211773 )

IMPC - KMPC

hematopoietic system

increased CD11b-high dendritic cell number ( J:211773 )

♂

IMPC - KMPC

increased CD8-positive, CD25-positive alpha-beta T cell number ( J:211773 )

IMPC - KMPC

increased CD4-negative, CD25-positive NK T cell number ( J:211773 )

IMPC - KMPC

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

♀

IMPC - KMPC

immune system

increased CD11b-high dendritic cell number ( J:211773 )

♂

IMPC - KMPC

increased CD8-positive, CD25-positive alpha-beta T cell number ( J:211773 )

IMPC - KMPC

increased CD4-negative, CD25-positive NK T cell number ( J:211773 )

IMPC - KMPC