Phenotypes associated with this allele

• Allele Symbol: Crim1^{em1(IMPC)Wtsi}
• Allele Name: endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:6153310
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crim1^em1(IMPC)Wtsi/Crim1^em1(IMPC)Wtsi	C57BL/6N-Crim1^em1(IMPC)Wtsi/WtsiOrl	MGI:6161266
ht2	Crim1^em1(IMPC)Wtsi/Crim1^+	C57BL/6N-Crim1^em1(IMPC)Wtsi/WtsiOrl	MGI:6262209

Genotype
MGI:6161266

hm1

• Allelic Composition: Crim1^{em1(IMPC)Wtsi}/Crim1^{em1(IMPC)Wtsi}
• Genetic Background: C57BL/6N-Crim1^{em1(IMPC)Wtsi}/WtsiOrl

Data Sources

IMPC Data for Crim1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

aortic arch coarctation ( J:239583 )

DMDD

anastomosis between internal carotid artery and basilar artery ( J:239583 )

DMDD

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

absent posterior communicating artery ( J:239583 )

DMDD

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal vitelline vein topology ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

absent ductus venosus ( J:239583 )

DMDD

abnormal hepatic portal vein connection ( J:239583 )

DMDD

pulmonary vein hypoplasia ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

telangiectasia ( J:239583 )

DMDD

craniofacial

abnormal Meckel's cartilage morphology ( J:239583 )

DMDD

fragmented Meckel's cartilage ( J:239583 )

DMDD

digestive/alimentary system

anal atresia ( J:239583 )

DMDD

decreased parotid gland size ( J:239583 )

DMDD

embryo

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal vitelline vein topology ( J:239583 )

DMDD

abnormal Mullerian duct topology ( J:239583 )

DMDD

endocrine/exocrine glands

decreased parotid gland size ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

immune system

absent connection between subcutaneous lymph vessels and lymph sac ( J:239583 )

DMDD

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

limbs/digits/tail

syndactyly ( J:239583 )

DMDD

liver/biliary system

herniated liver ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

muscle

telangiectasia ( J:239583 )

DMDD

nervous system

anastomosis between internal carotid artery and basilar artery ( J:239583 )

DMDD

absent segment of posterior cerebral artery ( J:239583 )

DMDD

absent posterior communicating artery ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

absent mandibular nerve ( J:239583 )

DMDD

fused dorsal root ganglion ( J:239583 )

DMDD

skeleton

abnormal Meckel's cartilage morphology ( J:239583 )

DMDD

fragmented Meckel's cartilage ( J:239583 )

DMDD

abnormal rib morphology ( J:239583 )

DMDD

abnormal vertebral arch morphology ( J:239583 )

DMDD

fusion of vertebral arches ( J:239583 )

DMDD

vision/eye

abnormal eye morphology ( J:239583 )

DMDD

lens dislocation ( J:239583 )

DMDD

retrolental blood ( J:239583 )

DMDD

Genotype
MGI:6262209

ht2

• Allelic Composition: Crim1^{em1(IMPC)Wtsi}/Crim1⁺
• Genetic Background: C57BL/6N-Crim1^{em1(IMPC)Wtsi}/WtsiOrl

Data Sources

IMPC Data for Crim1

behavior/neurological

trunk curl ( J:211773 )

♀

IMPC - WTSI