Phenotypes associated with this allele

• Allele Symbol: Rbbp4^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6152622
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbbp4^em1(IMPC)Mbp/Rbbp4^em1(IMPC)Mbp	C57BL/6NCrl-Rbbp4^em1(IMPC)Mbp/Mmucd	MGI:6263324
ht2	Rbbp4^em1(IMPC)Mbp/Rbbp4^+	C57BL/6NCrl-Rbbp4^em1(IMPC)Mbp/Mmucd	MGI:6263323

Genotype
MGI:6263324

hm1

• Allelic Composition: Rbbp4^em1(IMPC)Mbp/Rbbp4^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Rbbp4^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Rbbp4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

absent inner cell mass proliferation ( J:279207 )

• blastocysts hatch from the zona pellucida but fail to form typical outgrowth colonies after 3 days in culture

embryo

absent inner cell mass proliferation ( J:279207 )

• blastocysts hatch from the zona pellucida but fail to form typical outgrowth colonies after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - UCD

embryonic lethality before implantation, incomplete penetrance ( J:279207 )

• only 3% of blastocysts are recovered at E3.5

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• no homozygous embryos or excess resorption sites are observed at E7.5

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:6263323

ht2

• Allelic Composition: Rbbp4^em1(IMPC)Mbp/Rbbp4⁺
• Genetic Background: C57BL/6NCrl-Rbbp4^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Rbbp4

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - UCD

cardiovascular system

hemorrhage ( J:211773 )

IMPC - UCD

embryo

spina bifida ( J:211773 )

IMPC - UCD

endocrine/exocrine glands

abnormal gallbladder morphology ( J:211773 )

♀

IMPC - UCD

growth/size/body

microcephaly ( J:211773 )

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

limbs/digits/tail

polydactyly ( J:211773 )

IMPC - UCD

syndactyly ( J:211773 )

IMPC - UCD

liver/biliary system

abnormal gallbladder morphology ( J:211773 )

♀

IMPC - UCD

abnormal liver morphology ( J:211773 )

IMPC - UCD

small liver ( J:211773 )

♀

IMPC - UCD

nervous system

spina bifida ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

skeleton

increased bone mineral content ( J:211773 )

♀

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - UCD

microphthalmia ( J:211773 )

IMPC - UCD

abnormal retina morphology ( J:211773 )

IMPC - UCD

anophthalmia ( J:211773 )

IMPC - UCD