Analysis Tools
immune system
| N |
• at 6 to 8 weeks of age, mice show no differences in the ratio of naive T cells relative to control-mice
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• in response to CCL21 exposure, the displacement and velocity of primary T cells during migration on ICAM-1 are reduced to 43% and 58% of those in control T cells, respectively
• in transwell migration assays, the numbers of T cells that migrate to the lower chambers containing CCL21 are markedly lower than those of control T cells; the numbers of T cells that migrate through ICAM-1-coated filters is not reduced relative to the number of T cells that migrate through uncoated filters, unlike in control cells
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• in response to CCL21 exposure, primary T cells show a significant reduction in the shear stressresistant adhesion to ICAM-1 relative to control T cells
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• analysis of the homing capability of adoptively transferred T cells showed that the extent of T cell trafficking into the spleen and peripheral lymph nodes is reduced to ~50% and 30%, respectively, of that in control cells
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• spleen and peripheral lymph nodes show significantly lower numbers of T cells and B cells than control lymphoid tissues due to impaired lymphocyte trafficking
• however, numbers of T cells and B cells are normal in blood
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small spleen
(
J:259093
)
|
• spleen is significantly smaller than in control mice
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• upon stimulation with chemokine CCL21, Mst1 does not translocate to the leading edge but remains diffusely distributed in the cytoplasm of primary T cells, unlike in control T cells
• most CCL21-stimulated T cells show impaired redistribution of LFA-1, whereas ~30% of CCL21-treated control T cells display polarized morphologies with a leading edge and uropod, to which LFA-1 and CD44 are clustered, respectively
• however, the abundance of CCR7 (the receptor for CCL21) in T cells is similar to that in control T cells
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• inguinal lymph nodes are significantly smaller than in control mice
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• spleen and peripheral lymph nodes show significantly lower numbers of T cells and B cells than control lymphoid tissues
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hematopoietic system
|
• in response to CCL21 exposure, the displacement and velocity of primary T cells during migration on ICAM-1 are reduced to 43% and 58% of those in control T cells, respectively
• in transwell migration assays, the numbers of T cells that migrate to the lower chambers containing CCL21 are markedly lower than those of control T cells; the numbers of T cells that migrate through ICAM-1-coated filters is not reduced relative to the number of T cells that migrate through uncoated filters, unlike in control cells
|
|
• in response to CCL21 exposure, primary T cells show a significant reduction in the shear stressresistant adhesion to ICAM-1 relative to control T cells
|
|
• analysis of the homing capability of adoptively transferred T cells showed that the extent of T cell trafficking into the spleen and peripheral lymph nodes is reduced to ~50% and 30%, respectively, of that in control cells
|
|
• spleen and peripheral lymph nodes show significantly lower numbers of T cells and B cells than control lymphoid tissues due to impaired lymphocyte trafficking
• however, numbers of T cells and B cells are normal in blood
|
small spleen
(
J:259093
)
|
• spleen is significantly smaller than in control mice
|
|
• upon stimulation with chemokine CCL21, Mst1 does not translocate to the leading edge but remains diffusely distributed in the cytoplasm of primary T cells, unlike in control T cells
• most CCL21-stimulated T cells show impaired redistribution of LFA-1, whereas ~30% of CCL21-treated control T cells display polarized morphologies with a leading edge and uropod, to which LFA-1 and CD44 are clustered, respectively
• however, the abundance of CCR7 (the receptor for CCL21) in T cells is similar to that in control T cells
|
cellular
|
• in response to CCL21 exposure, the displacement and velocity of primary T cells during migration on ICAM-1 are reduced to 43% and 58% of those in control T cells, respectively
• in transwell migration assays, the numbers of T cells that migrate to the lower chambers containing CCL21 are markedly lower than those of control T cells; the numbers of T cells that migrate through ICAM-1-coated filters is not reduced relative to the number of T cells that migrate through uncoated filters, unlike in control cells
|
|
• in response to CCL21 exposure, primary T cells show a significant reduction in the shear stressresistant adhesion to ICAM-1 relative to control T cells
|
|
• analysis of the homing capability of adoptively transferred T cells showed that the extent of T cell trafficking into the spleen and peripheral lymph nodes is reduced to ~50% and 30%, respectively, of that in control cells
|
mortality/aging
| N |
• mice are born with the expected Mendelian frequencies and grow normally
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growth/size/body
| N |
• mice grow normally
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