Rab13^tm1.1Ktg
Targeted Allele Detail

Summary

• Symbol: Rab13^tm1.1Ktg
• Name: RAB13, member RAS oncogene family; targeted mutation 1.1 Koko Katagiri
• MGI ID: MGI:6151445
• Synonyms: Rab13^-
• Gene: Rab13 Location: Chr3:90121022-90133694 bp, + strand Genetic Position: Chr3, 39.21 cM, cytoband F2
• Alliance: Rab13^tm1.1Ktg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259093
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted to flank exon 1. An frt-flanked neomycin selection cassette was also inserted 3' to exon 1. Cre-mediated recombination of the loxP sites resulted in a deletion of exon 1 and the neomycin selection cassette. Western blot analysis confirmed the absence of encoded protein in T cells from homozygous mutant mice. (J:259093)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab13 Mutation: 36 strains or lines available

References

• Original: J:259093 Nishikimi A, et al., Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking. Sci Signal. 2014 Jul 29;7(336):ra72
• All: 1 reference(s)