Phenotypes associated with this allele

• Allele Symbol: Sh3bp2^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6150886
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh3bp2^tm1c(KOMP)Wtsi/Sh3bp2^tm1c(KOMP)Wtsi	involves: C57BL/6N	MGI:6150898
cn2	Rnf146^tm1.1Rtpl/Rnf146^tm1.1Rtpl Sh3bp2^tm1c(KOMP)Wtsi/Sh3bp2^tm1c(KOMP)Wtsi Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6150899

Genotype
MGI:6150898

hm1

• Allelic Composition: Sh3bp2^{tm1c(KOMP)Wtsi}/Sh3bp2^{tm1c(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0129_3_C05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased bone mineral density ( J:243612 )

• in trabecular bone

increased trabecular bone volume ( J:243612 )

abnormal compact bone morphology ( J:243612 )

• reduced cortical periosteal, but not endosteal, perimeter

increased compact bone thickness ( J:243612 )

• with increased cortical major, but not minor, diameter

increased bone trabecula number ( J:243612 )

increased trabecular bone thickness ( J:243612 )

• however, trabecular separation is normal

increased bone mass ( J:243612 )

Genotype
MGI:6150899

cn2

• Allelic Composition: Rnf146^tm1.1Rtpl/Rnf146^tm1.1Rtpl; Sh3bp2^{tm1c(KOMP)Wtsi}/Sh3bp2^{tm1c(KOMP)Wtsi}; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
• Cell Lines: EPD0129_3_C05

skeleton

skeleton phenotype ( J:243612 )

N • mice exhibit normal trabecular bone volume, trabecular bone mineral density, trabecular number, cortical thickness, cortical major and minor diameter, cortical periosteal and endosteal perimeter, and trabecular separation