Analysis Tools
immune system
| N |
• unlike plt mice, mice exhibit normal numbers of double negative thymocytes, DN1, DN2, DN3 and DN4 cells
• mice exhibit normal regulatory T cell production
|
|
• small and scattered as in plt mice
|
|
• reduced accumulation of mature thymocytes
|
|
• autoimmune dacryoadenitis by 20 weeks
|
|
• in the thymus
|
|
• in lymph nodes, but not spleen, as in plt mice
|
|
• reduced T cells in the white pulp but increased T cells in the red pulp compared to in wild-type mice
|
vision/eye
|
• autoimmune dacryoadenitis by 20 weeks
|
endocrine/exocrine glands
|
• small and scattered as in plt mice
|
|
• reduced accumulation of mature thymocytes
|
|
• autoimmune dacryoadenitis by 20 weeks
|
hematopoietic system
|
• small and scattered as in plt mice
|
|
• reduced accumulation of mature thymocytes
|
|
• in the thymus
|
|
• in lymph nodes, but not spleen, as in plt mice
|
|
• reduced T cells in the white pulp but increased T cells in the red pulp compared to in wild-type mice
|
