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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ccl21atm1Yout
targeted mutation 1, Yousuke Takahama
MGI:6149979
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ccl21atm1Yout/Ccl21atm1Yout involves: C57BL/6NCrlj * CBA/JNCrlj MGI:6149990


Genotype
MGI:6149990
hm1
Allelic
Composition
Ccl21atm1Yout/Ccl21atm1Yout
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl21atm1Yout mutation (0 available); any Ccl21a mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike plt mice, mice exhibit normal numbers of double negative thymocytes, DN1, DN2, DN3 and DN4 cells
• mice exhibit normal regulatory T cell production
• small and scattered as in plt mice
• reduced accumulation of mature thymocytes
• autoimmune dacryoadenitis by 20 weeks
• in the thymus
• in lymph nodes, but not spleen, as in plt mice
• reduced T cells in the white pulp but increased T cells in the red pulp compared to in wild-type mice

vision/eye
• autoimmune dacryoadenitis by 20 weeks

endocrine/exocrine glands
• small and scattered as in plt mice
• reduced accumulation of mature thymocytes
• autoimmune dacryoadenitis by 20 weeks

hematopoietic system
• small and scattered as in plt mice
• reduced accumulation of mature thymocytes
• in the thymus
• in lymph nodes, but not spleen, as in plt mice
• reduced T cells in the white pulp but increased T cells in the red pulp compared to in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory