Ccl21a^tm1Yout
Targeted Allele Detail

Summary

• Symbol: Ccl21a^tm1Yout
• Name: C-C motif chemokine ligand 21 (serine); targeted mutation 1, Yousuke Takahama
• MGI ID: MGI:6149979
• Gene: Ccl21a Location: Chr4:42772860-42773991 bp, - strand Genetic Position: Chr4, 22.43 cM
• Alliance: Ccl21a^tm1Yout page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244640
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A tdTomato reporter gene and floxed neomycin resistance cassette replaced the coding sequence in exon 1. QRT-PCR confirmed the absence of transcript expression in thymus, peripheral lymph nodes, mesenteric lymph nodes, spleen and lung. (J:244640)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccl21a Mutation: 5 strains or lines available

References

• Original: J:244640 Kozai M, et al., Essential role of CCL21 in establishment of central self-tolerance in T cells. J Exp Med. 2017 Jul 03;214(7):1925-1935
• All: 5 reference(s)