Phenotypes associated with this allele

• Allele Symbol: Rbm24^tm1.1Xch
• Allele Name: targeted mutation 1.1, Xinbin Chen
• Allele ID: MGI:6149956
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbm24^tm1.1Xch/Rbm24^tm1.1Xch	involves: FVB/N	MGI:6152434
cx2	Rbm24^tm1.1Xch/Rbm24^tm1.1Xch Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:6152435
cx3	Rbm24^tm1.1Xch/Rbm24^tm1.1Xch Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:6152436

Genotype
MGI:6152434

hm1

• Allelic Composition: Rbm24^tm1.1Xch/Rbm24^tm1.1Xch
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:259290 )

• mice die between E12.5 and E13.5

cardiovascular system

myocardial trabeculae hypoplasia ( J:259290 )

thin atrioventricular cushion ( J:259290 )

• with fewer cells at E10.5 and E11.5

failure of atrioventricular cushion closure ( J:259290 )

• inadequate or abnormal fusion of the superior and inferior endocardial cushions

embryo

increased embryonic tissue cell apoptosis ( J:259290 )

• in heart tissue at E10.5 and E11.5

embryonic growth retardation ( J:259290 )

• at E12.5 and E13.5

cellular

increased embryonic tissue cell apoptosis ( J:259290 )

• in heart tissue at E10.5 and E11.5

growth/size/body

embryonic growth retardation ( J:259290 )

• at E12.5 and E13.5

muscle

myocardial trabeculae hypoplasia ( J:259290 )

Genotype
MGI:6152435

cx2

• Allelic Composition: Rbm24^tm1.1Xch/Rbm24^tm1.1Xch; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

mortality/aging

abnormal survival ( J:259290 )

• unlike Rbm24^tm1.1Xch homozygotes, some mice are viable and exhibit no obvious defects with partial rescue of embryonic lethality

cardiovascular system

cardiovascular system phenotype ( J:259290 )

N • unlike Rbm24^tm1.1Xch homozygotes, some mice are viable and exhibit no obvious defects with normal endocardial cushions with rescue of cardiac tissue apoptosis

Genotype
MGI:6152436

cx3

• Allelic Composition: Rbm24^tm1.1Xch/Rbm24^tm1.1Xch; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

cardiovascular system

cardiovascular system phenotype ( J:259290 )

N • unlike Rbm24^tm1.1Xch homozygotes, mice exhibit normal endocardial cushions with rescue of cardiac tissue apoptosis

growth/size/body

fetal growth retardation ( J:259290 )

• at E18.5