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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Golgb1m1Lanyu
mutation 1, Yu Lan
MGI:6149903
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Golgb1m1Lanyu/Golgb1m1Lanyu A/J-Golgb1m1Lanyu MGI:6151463
ht2
 		Golgb1em33Lanyu/Golgb1m1Lanyu involves: A/J * FVB/NJ MGI:6151460


Genotype
MGI:6151463
hm1
Allelic
Composition		 Golgb1m1Lanyu/Golgb1m1Lanyu
Genetic
Background		 A/J-Golgb1m1Lanyu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Golgb1m1Lanyu mutation (0 available); any Golgb1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:235669 )
N
• normal palatal cell proliferation in mesenchyme and epithelium in E12.5-13.5 embryos; palatal shelves shape and size like controls up to E13.5
abnormal palate development ( J:235669 )
• smaller palatal shelves than controls after E13.5, with higher cellular density throughout anterior-posterior axis
• less Alcian Blue staining in palatal mesenchyme after E13.5
• reduced hyaluronan (HA) accumulation throughout anterior-posterior axis of palatal mesenchyme at E13.5
• reduced hyaluronan (HA) accumulation in hinge region and at nasal side of palatal mesenchyme at E13.5
palatal shelves fail to meet at midline ( J:235669 )
• un-fused palatal shelves in E15.5 and E16.5 embryos
decreased palatal shelf size ( J:235669 )
• smaller palatal shelves than controls after E13.5
cleft palate ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
abnormal tongue position ( J:235669 )
• failure of tongue to descend to oral cavity floor in E14.5-16.5 embryos

digestive/alimentary system
abnormal palate development ( J:235669 )
• smaller palatal shelves than controls after E13.5, with higher cellular density throughout anterior-posterior axis
• less Alcian Blue staining in palatal mesenchyme after E13.5
• reduced hyaluronan (HA) accumulation throughout anterior-posterior axis of palatal mesenchyme at E13.5
• reduced hyaluronan (HA) accumulation in hinge region and at nasal side of palatal mesenchyme at E13.5
palatal shelves fail to meet at midline ( J:235669 )
• un-fused palatal shelves in E15.5 and E16.5 embryos
decreased palatal shelf size ( J:235669 )
• smaller palatal shelves than controls after E13.5
cleft palate ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
abnormal tongue position ( J:235669 )
• failure of tongue to descend to oral cavity floor in E14.5-16.5 embryos

embryo
embryo phenotype ( J:235669 )
N
• neural crest cell migration and differentiation from E9.5-12.5

growth/size/body
abnormal palate development ( J:235669 )
• smaller palatal shelves than controls after E13.5, with higher cellular density throughout anterior-posterior axis
• less Alcian Blue staining in palatal mesenchyme after E13.5
• reduced hyaluronan (HA) accumulation throughout anterior-posterior axis of palatal mesenchyme at E13.5
• reduced hyaluronan (HA) accumulation in hinge region and at nasal side of palatal mesenchyme at E13.5
palatal shelves fail to meet at midline ( J:235669 )
• un-fused palatal shelves in E15.5 and E16.5 embryos
decreased palatal shelf size ( J:235669 )
• smaller palatal shelves than controls after E13.5
cleft palate ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
abnormal tongue position ( J:235669 )
• failure of tongue to descend to oral cavity floor in E14.5-16.5 embryos

homeostasis/metabolism
decreased hyaluronic acid level ( J:235669 )
• reduced hyaluronan (HA) accumulation throughout anterior-posterior axis of palatal mesenchyme at E13.5
• reduced HA accumulation in hinge region and at nasal side of palatal mesenchyme at E13.5

cellular
cellular phenotype ( J:235669 )
N
• Golgi apparatus morphology is normal

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cleft palate DOID:674 J:235669




Genotype
MGI:6151460
ht2
Allelic
Composition		 Golgb1em33Lanyu/Golgb1m1Lanyu
Genetic
Background		 involves: A/J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Golgb1em33Lanyu mutation (0 available); any Golgb1 mutation (117 available)
Golgb1m1Lanyu mutation (0 available); any Golgb1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:235669 )
• vertically oriented un-fused palatal shelves in E16.5-18.5 embryos
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in E16.5-18.5 embryos

digestive/alimentary system
cleft palate ( J:235669 )
• vertically oriented un-fused palatal shelves in E16.5-18.5 embryos
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in E16.5-18.5 embryos

growth/size/body
cleft palate ( J:235669 )
• vertically oriented un-fused palatal shelves in E16.5-18.5 embryos
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in E16.5-18.5 embryos

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cleft palate DOID:674 J:235669




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory