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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp949tm1Htno
targeted mutation 1, Masahiko Hatano
MGI:6149131
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp949tm1Htno/Zfp949tm1Htno involves: 129S1/Sv * 129X1/SvJ MGI:6152407
cx2
 		Cdkn1btm1Kin/Cdkn1btm1Kin
Zfp949tm1Htno/Zfp949tm1Htno 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:6152408


Genotype
MGI:6152407
hm1
Allelic
Composition		 Zfp949tm1Htno/Zfp949tm1Htno
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp949tm1Htno mutation (0 available); any Zfp949 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:259302 )
• no viable mice are found after E10.5
embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:259302 )
• fewer than expected mice are present at E8.5 and E9.5

embryo
abnormal embryo development ( J:259302 )
• at E8.5 and E9.5
decreased embryo size ( J:259302 )
• at E6.5, E7.5, E8.5 and E9.5
abnormal neural plate morphology ( J:259302 )
• disorganized and generally hypocellularity at E9.5

growth/size/body
embryonic growth retardation ( J:259302 )
decreased embryo size ( J:259302 )
• at E6.5, E7.5, E8.5 and E9.5

cellular

nervous system
abnormal neural plate morphology ( J:259302 )
• disorganized and generally hypocellularity at E9.5




Genotype
MGI:6152408
cx2
Allelic
Composition		 Cdkn1btm1Kin/Cdkn1btm1Kin
Zfp949tm1Htno/Zfp949tm1Htno
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm1Kin mutation (1 available); any Cdkn1b mutation (25 available)
Zfp949tm1Htno mutation (0 available); any Zfp949 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:259302 )
• fewer than expected mice are present at E9.5, E10.5 and E11.5
• no mice are recovered after E11.5

embryo
abnormal embryo turning ( J:259302 )
• some turning at E10.5

growth/size/body
decreased embryo size ( J:259302 )

cellular
decreased cell proliferation ( J:259302 )
• not as severe as in Zfp949tm1Htno homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory