Analysis Tools
behavior/neurological
| N |
• normal neuromuscular strength as measured by grip strength and wire hang tests
• no significant changes in gait, motor coordination, sensorimotor gating, anxiety, depressive-related behavior, stereotypic activity or social behavior
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• enhanced methamphetamine-induced locomotor activity in open field test, with a greater increase in locomotor sensitization than wild-type controls in response to repeated administration (1 mg/kg of body weight for 5 consecutive days), that becomes significant after 3 days of injection
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• moderate but significant increase in vertical rearing activity in open field test
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• mild increase in total distance traveled in open field test
• significant increase in total distance traveled and number of transitions in light-dark transition test
• increase in distance traveled in social interaction test, with no increase in the number of social contacts
• significant increase in total distance traveled, but no depression-related behavior, in Porsolt forced swim test
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nervous system
| N |
• unexpectedly, gross hippocampus anatomy is normal with no morphological alterations in the cells of CA regions at 3 months of age
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homeostasis/metabolism
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• increase in the extracellular concentration (release) of dopamine in the nucleus accumbens after repeated injections of methamphetamine compared with levels after single injection
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