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Miattm1Shna
Targeted Allele Detail
Summary
Symbol: Miattm1Shna
Name: myocardial infarction associated transcript (non-protein coding); targeted mutation 1, Shinichi Nakagawa
MGI ID: MGI:6148230
Synonyms: Gomafunull
Gene: Miat  Location: Chr5:112361094-112376814 bp, - strand  Genetic Position: Chr5, 54.59 cM
Alliance: Miattm1Shna page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:250154
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsMice carrying this allele were generated using TAMERE technology. Embryonic stem (ES) cells bearing insertions of a loxP-PGK-Neo cassette into the first exon (5'delta) or into the polyadenylation signal (3'delta) were generated. Chimeric mice were generated with the recombinant ES clones and were subsequently mated with transgenic mice (B6;D2-Tg(Sycp1-cre)4 Min/J) that express the Cre recombinase under the control of Sycp1 to generate double heterozygous mice. These mice were inter-crossed to generate trans-heterozygous (5'delta/3'delta) mice with the Sycp1-Cre transgene. Male mice produced sperm that had the alleles completely deleted and were studied further. (J:250154)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Miat Mutation:  0 strains or lines available
References
Original:  J:250154 Ip JY, et al., Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 2016 Jun 2;6:27204
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory