Analysis Tools
behavior/neurological
| N |
• behavior in olfaction and cage-top hang tests
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• increased immobility in forced swimming test
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• increase in total distance travelled in the open field test with less time spent in center
• significant increase in number of repetitive jumps in open field test
• higher frequencies of times digging and marble burying during marble burying test
• in light-dark test
• mostly rescued by prenatal treatment with Tubastatin A
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• higher frequencies of times digging and marble burying during marble burying test
• mostly rescued by prenatal treatment with Tubastatin A
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• less time spent grooming at age P21
• mostly rescued by prenatal treatment with Tubastatin A
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• significant increase in number of repetitive jumps in open field test
• mostly rescued by prenatal treatment with Tubastatin A
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• increase in total distance traveled in the open field test: increase in travel time without increase in velocity; less time spent in center
• mostly rescued by prenatal treatment with Tubastatin A
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• sensory hyposensitivity in hot plate test
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nervous system
| N |
• brain weight and morphology
• neuronal proliferation rate and differentiation
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• delayed or failed migration of some Cux1-positive cells to layers II and III of somatosensory cortex at age P2 and P21
• mostly rescued by prenatal treatment with Tubastatin A
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• some cortical layer II/III type neurons that failed to migrate from layer V showed axons projecting into ipsilateral striatum at age P21 and P56
• mostly rescued by prenatal treatment with Tubastatin A
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cellular
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• delayed or failed migration of some Cux1-positive cells to layers II and III of somatosensory cortex at age P2 and P21
• mostly rescued by prenatal treatment with Tubastatin A
|
mortality/aging
| N |
• viable
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growth/size/body
| N |
• morphology, and body weight at birth and at juvenile stage
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reproductive system
| N |
• fertile
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