Ccdc141^tm1.1Ygi
Targeted Allele Detail

Summary

• Symbol: Ccdc141^tm1.1Ygi
• Name: coiled-coil domain containing 141; targeted mutation 1.1, Shigeru Yanagi
• MGI ID: MGI:6148229
• Synonyms: CAMDI-KO
• Gene: Ccdc141 Location: Chr2:76840246-77000980 bp, - strand Genetic Position: Chr2, 45.38 cM, cytoband D
• Alliance: Ccdc141^tm1.1Ygi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238090
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination of loxP sites surrounding exon 4 resulted in a null mutation. An frt-flanked neomycin selection cassette was inserted in intron 3. Western blot analysis of E16 mouse brain lysate demonstrated an absence of the encoded protein in homozygous mice. (J:238090)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc141 Mutation: 80 strains or lines available

References

• Original: J:238090 Fukuda T, et al., Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. EMBO Rep. 2016 Dec;17(12):1785-1798
• All: 2 reference(s)