About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polrmttm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:6147647
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Polrmttm1.1Arte/Polrmttm1.1Arte
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6N * FVB MGI:6147657


Genotype
MGI:6147657
cn1
Allelic
Composition		 Polrmttm1.1Arte/Polrmttm1.1Arte
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polrmttm1.1Arte mutation (0 available); any Polrmt mutation (44 available)
Tg(Ckmm-cre)5Khn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:258184 )
• all die before 6 weeks of age

cardiovascular system
dilated cardiomyopathy ( J:258184 )
• progressive enlargement of the heart with dilation of the left ventricular chamber
decreased heart rate variability ( J:258184 )
• 40% reduction in heart rate variability in older mice

cellular
abnormal mitochondrial morphology ( J:258184 )
• disorganized cristae
abnormal mitochondrial physiology ( J:258184 )
• severe mitochondrial dysfunction in the heart of terminal stage mice

muscle
dilated cardiomyopathy ( J:258184 )
• progressive enlargement of the heart with dilation of the left ventricular chamber




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory