Phenotypes associated with this allele

• Allele Symbol: Morc2a^{em1(IMPC)Wtsi}
• Allele Name: endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:6140214
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Morc2a^em1(IMPC)Wtsi/Morc2a^em1(IMPC)Wtsi	C57BL/6N-Morc2a^em1(IMPC)Wtsi/WtsiOulu	MGI:6161268
ht2	Morc2a^em1(IMPC)Wtsi/Morc2a^+	C57BL/6N-Morc2a^em1(IMPC)Wtsi/WtsiOulu	MGI:6262900

Genotype
MGI:6161268

hm1

• Allelic Composition: Morc2a^{em1(IMPC)Wtsi}/Morc2a^{em1(IMPC)Wtsi}
• Genetic Background: C57BL/6N-Morc2a^{em1(IMPC)Wtsi}/WtsiOulu

Data Sources

IMPC Data for Morc2a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

persistent dorsal ophthalmic artery ( J:239583 )

DMDD

aberrant origin of the right subclavian artery ( J:239583 )

DMDD

right aortic arch ( J:239583 )

DMDD

left sided brachiocephalic trunk ( J:239583 )

DMDD

abnormal internal carotid artery topology ( J:239583 )

DMDD

abnormal celiac artery morphology ( J:239583 )

DMDD

abnormal anterior cerebral artery morphology ( J:239583 )

DMDD

absent segment of anterior cerebral artery ( J:239583 )

DMDD

retroesophageal left subclavian artery ( J:239583 )

DMDD

abnormal subclavian artery origin ( J:239583 )

DMDD

abnormal vertebral artery origin ( J:239583 )

DMDD

absent intracranial segment of vertebral artery ( J:239583 )

DMDD

absent posterior communicating artery ( J:239583 )

DMDD

absent stapedial artery ( J:239583 )

DMDD

abnormal liver vasculature morphology ( J:239583 )

DMDD

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal ductus venosus topology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

abnormal inferior vena cava morphology ( J:239583 )

DMDD

absent intrahepatic inferior vena cava segment ( J:239583 )

DMDD

abnormal pectinate muscle morphology ( J:239583 )

DMDD

persistent truncus arteriosus ( J:239583 )

DMDD

abnormal atrioventricular cushion morphology ( J:239583 )

DMDD

double outlet right ventricle ( J:239583 )

DMDD

double inlet heart right ventricle ( J:239583 )

DMDD

abnormal interatrial septum morphology ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

intracerebral hemorrhage ( J:239583 )

DMDD

craniofacial

abnormal Meckel's cartilage morphology ( J:239583 )

DMDD

fragmented Meckel's cartilage ( J:239583 )

DMDD

abnormal occipital bone morphology ( J:239583 )

DMDD

absent occipital bone ( J:239583 )

DMDD

abnormal sphenoid bone morphology ( J:239583 )

DMDD

basisphenoid bone foramen ( J:239583 )

DMDD

absent neurocranium ( J:239583 )

DMDD

abnormal hyoid bone body morphology ( J:239583 )

DMDD

abnormal jaw morphology ( J:239583 )

DMDD

abnormal incisor morphology ( J:239583 )

DMDD

absent upper incisors ( J:239583 )

DMDD

abnormal middle ear ossicle morphology ( J:239583 )

DMDD

abnormal stapes morphology ( J:239583 )

DMDD

abnormal masticatory muscle morphology ( J:239583 )

DMDD

tongue hypoplasia ( J:239583 )

DMDD

short tongue ( J:239583 )

DMDD

abnormal nasal cavity morphology ( J:239583 )

DMDD

abnormal nasal septum morphology ( J:239583 )

DMDD

abnormal vomeronasal organ morphology ( J:239583 )

DMDD

facial cleft ( J:239583 )

DMDD

abnormal external auditory canal morphology ( J:239583 )

DMDD

absent external auditory canal ( J:239583 )

DMDD

digestive/alimentary system

tongue hypoplasia ( J:239583 )

DMDD

short tongue ( J:239583 )

DMDD

abnormal intestine placement ( J:239583 )

DMDD

abnormal salivary gland morphology ( J:239583 )

DMDD

absent salivary gland ( J:239583 )

DMDD

embryo

abnormal vitelline vein connection ( J:239583 )

DMDD

embryonic growth retardation ( J:239583 )

DMDD

abnormal Mullerian duct morphology ( J:239583 )

DMDD

absent Mullerian ducts ( J:239583 )

DMDD

abnormal Wolffian duct morphology ( J:239583 )

DMDD

abnormal Wolffian duct topology ( J:239583 )

DMDD

absent Wolffian ducts ( J:239583 )

DMDD

endocrine/exocrine glands

abnormal salivary gland morphology ( J:239583 )

DMDD

absent salivary gland ( J:239583 )

DMDD

abnormal common bile duct morphology ( J:239583 )

DMDD

abnormal adrenal gland morphology ( J:239583 )

DMDD

small adrenal glands ( J:239583 )

DMDD

abnormal pituitary gland morphology ( J:239583 )

DMDD

absent pituitary gland ( J:239583 )

DMDD

abnormal pineal gland morphology ( J:239583 )

DMDD

small thymus ( J:239583 )

DMDD

abnormal thymus topology ( J:239583 )

DMDD

athymia ( J:239583 )

DMDD

abnormal thyroid gland morphology ( J:239583 )

DMDD

small thyroid gland ( J:239583 )

DMDD

abnormal dorsal pancreas topology ( J:239583 )

DMDD

small dorsal pancreas ( J:239583 )

DMDD

absent ventral pancreas ( J:239583 )

DMDD

small ventral pancreas ( J:239583 )

DMDD

small pancreas ( J:239583 )

DMDD

small ovary ( J:239583 )

DMDD

abnormal testis morphology ( J:239583 )

DMDD

growth/size/body

embryonic growth retardation ( J:239583 )

DMDD

thoracoschisis ( J:239583 )

DMDD

liver cyst ( J:239583 )

DMDD

abnormal head morphology ( J:239583 )

DMDD

abnormal hyoid bone body morphology ( J:239583 )

DMDD

abnormal jaw morphology ( J:239583 )

DMDD

abnormal incisor morphology ( J:239583 )

DMDD

absent upper incisors ( J:239583 )

DMDD

abnormal masticatory muscle morphology ( J:239583 )

DMDD

tongue hypoplasia ( J:239583 )

DMDD

short tongue ( J:239583 )

DMDD

abnormal nasal cavity morphology ( J:239583 )

DMDD

abnormal nasal septum morphology ( J:239583 )

DMDD

abnormal vomeronasal organ morphology ( J:239583 )

DMDD

facial cleft ( J:239583 )

DMDD

abnormal external auditory canal morphology ( J:239583 )

DMDD

absent external auditory canal ( J:239583 )

DMDD

heterochrony ( J:239583 )

DMDD

hearing/vestibular/ear

abnormal external auditory canal morphology ( J:239583 )

DMDD

absent external auditory canal ( J:239583 )

DMDD

abnormal inner ear morphology ( J:239583 )

DMDD

abnormal middle ear morphology ( J:239583 )

DMDD

absent stapedial artery ( J:239583 )

DMDD

abnormal middle ear ossicle morphology ( J:239583 )

DMDD

abnormal stapes morphology ( J:239583 )

DMDD

hematopoietic system

small thymus ( J:239583 )

DMDD

abnormal thymus topology ( J:239583 )

DMDD

athymia ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

immune system

small thymus ( J:239583 )

DMDD

abnormal thymus topology ( J:239583 )

DMDD

athymia ( J:239583 )

DMDD

absent connection between subcutaneous lymph vessels and lymph sac ( J:239583 )

DMDD

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

limbs/digits/tail

abnormal carpal bone morphology ( J:239583 )

DMDD

oligodactyly ( J:239583 )

DMDD

abnormal forelimb morphology ( J:239583 )

DMDD

abnormal humerus morphology ( J:239583 )

DMDD

absent humerus ( J:239583 )

DMDD

abnormal radius morphology ( J:239583 )

DMDD

absent radius ( J:239583 )

DMDD

abnormal ulna morphology ( J:239583 )

DMDD

liver/biliary system

abnormal common bile duct morphology ( J:239583 )

DMDD

abnormal liver morphology ( J:239583 )

DMDD

abnormal liver vasculature morphology ( J:239583 )

DMDD

liver cyst ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal pectinate muscle morphology ( J:239583 )

DMDD

abnormal masticatory muscle morphology ( J:239583 )

DMDD

abnormal eye muscle morphology ( J:239583 )

DMDD

absent eye muscles ( J:239583 )

DMDD

abnormal diaphragm morphology ( J:239583 )

DMDD

diaphragmatic hernia ( J:239583 )

DMDD

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

absent digastric muscle ( J:239583 )

DMDD

neoplasm

increased trigeminal neuroma incidence ( J:239583 )

DMDD

nervous system

intracerebral hemorrhage ( J:239583 )

DMDD

abnormal vomeronasal organ morphology ( J:239583 )

DMDD

increased trigeminal neuroma incidence ( J:239583 )

DMDD

absent superior cervical ganglion ( J:239583 )

DMDD

reduced sympathetic cervical ganglion size ( J:239583 )

DMDD

abnormal brain morphology ( J:239583 )

DMDD

abnormal anterior cerebral artery morphology ( J:239583 )

DMDD

absent segment of anterior cerebral artery ( J:239583 )

DMDD

absent posterior communicating artery ( J:239583 )

DMDD

holoprosencephaly ( J:239583 )

DMDD

enlarged brain ventricles ( J:239583 )

DMDD

abnormal choroid plexus morphology ( J:239583 )

DMDD

abnormal brain internal capsule morphology ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

abnormal pituitary gland morphology ( J:239583 )

DMDD

absent pituitary gland ( J:239583 )

DMDD

abnormal pineal gland morphology ( J:239583 )

DMDD

abnormal olfactory bulb morphology ( J:239583 )

DMDD

abnormal olfactory bulb position ( J:239583 )

DMDD

abnormal hindbrain morphology ( J:239583 )

DMDD

small trigeminal ganglion ( J:239583 )

DMDD

abnormal facial nerve topology ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

abnormal olfactory nerve morphology ( J:239583 )

DMDD

absent optic chiasm ( J:239583 )

DMDD

absent mandibular nerve ( J:239583 )

DMDD

abnormal intrathoracic topology of vagus nerve ( J:239583 )

DMDD

renal/urinary system

small kidney ( J:239583 )

DMDD

abnormal ureter topology ( J:239583 )

DMDD

reproductive system

small ovary ( J:239583 )

DMDD

abnormal testis morphology ( J:239583 )

DMDD

respiratory system

abnormal nasal cavity morphology ( J:239583 )

DMDD

abnormal nasal septum morphology ( J:239583 )

DMDD

abnormal vomeronasal organ morphology ( J:239583 )

DMDD

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

absent digastric muscle ( J:239583 )

DMDD

abnormal left lung morphology ( J:239583 )

DMDD

abnormal right lung morphology ( J:239583 )

DMDD

skeleton

abnormal Meckel's cartilage morphology ( J:239583 )

DMDD

fragmented Meckel's cartilage ( J:239583 )

DMDD

abnormal occipital bone morphology ( J:239583 )

DMDD

absent occipital bone ( J:239583 )

DMDD

abnormal sphenoid bone morphology ( J:239583 )

DMDD

basisphenoid bone foramen ( J:239583 )

DMDD

absent neurocranium ( J:239583 )

DMDD

abnormal hyoid bone body morphology ( J:239583 )

DMDD

abnormal jaw morphology ( J:239583 )

DMDD

abnormal incisor morphology ( J:239583 )

DMDD

absent upper incisors ( J:239583 )

DMDD

abnormal middle ear ossicle morphology ( J:239583 )

DMDD

abnormal stapes morphology ( J:239583 )

DMDD

abnormal carpal bone morphology ( J:239583 )

DMDD

abnormal humerus morphology ( J:239583 )

DMDD

absent humerus ( J:239583 )

DMDD

abnormal radius morphology ( J:239583 )

DMDD

absent radius ( J:239583 )

DMDD

abnormal ulna morphology ( J:239583 )

DMDD

abnormal clavicle morphology ( J:239583 )

DMDD

abnormal scapula morphology ( J:239583 )

DMDD

abnormal rib morphology ( J:239583 )

DMDD

abnormal vertebral arch morphology ( J:239583 )

DMDD

abnormal vertebral body morphology ( J:239583 )

DMDD

absent vertebral body ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

absent eye muscles ( J:239583 )

DMDD

absent optic chiasm ( J:239583 )

DMDD

abnormal lens morphology ( J:239583 )

DMDD

aphakia ( J:239583 )

DMDD

abnormal optic cup morphology ( J:239583 )

DMDD

abnormal optic stalk morphology ( J:239583 )

DMDD

Genotype
MGI:6262900

ht2

• Allelic Composition: Morc2a^{em1(IMPC)Wtsi}/Morc2a⁺
• Genetic Background: C57BL/6N-Morc2a^{em1(IMPC)Wtsi}/WtsiOulu

Data Sources

IMPC Data for Morc2a

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - WTSI