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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Amotl2tm1.1Laho
targeted mutation 1.1, Lars Holmgren
MGI:6120889
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Amotl2tm1.1Laho/Amotl2tm1.1Laho
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: C57BL/6 MGI:6121065
cn2
 		Amotl2tm1.1Laho/Amotl2+
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: C57BL/6 MGI:6121066


Genotype
MGI:6121065
cn1
Allelic
Composition		 Amotl2tm1.1Laho/Amotl2tm1.1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl2tm1.1Laho mutation (0 available); any Amotl2 mutation (54 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:226656 )
N
• postnatal retinal angiogenesis
abnormal aorta morphology ( J:226656 )
• embryo aortic endothelial cells shaped short and rounded
aorta stenosis ( J:226656 )
• in 80% of E9.5 embryos
abnormal vascular endothelial cell morphology ( J:226656 )
• embryo aortic endothelial cells shaped short and rounded
• endothelium of embryo posterior cardinal vein (PCV), intersegmental vessels (ISVs) and brain vascular plexus




Genotype
MGI:6121066
cn2
Allelic
Composition		 Amotl2tm1.1Laho/Amotl2+
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl2tm1.1Laho mutation (0 available); any Amotl2 mutation (54 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aorta morphology ( J:226656 )
• embryo aortic endothelial cells shaped short and rounded
aorta stenosis ( J:226656 )
• in 80% of E9.5 embryos
abnormal vascular endothelial cell morphology ( J:226656 )
• embryo aortic endothelial cells shaped short and rounded




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory