Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll4tm1b(EUCOMM)Hmgu mutation
(1 available);
any
Vgll4 mutation
(24 available)
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Data Sources
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll4tm1b(EUCOMM)Hmgu mutation
(1 available);
any
Vgll4 mutation
(24 available)
|
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mortality/aging
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• all mice die within 14 weeks of birth
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cardiovascular system
N |
• at neonatal stages, mitral and tricuspid valves appear normal
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• increased proliferation of valvar interstitial cells in E15.5 heart valves
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• relative to body weight
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• at adult and neonatal stages
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• at adult and neonatal stages
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• increased velocity and pressure gradient across the aortic valves
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• increased ejection fraction and fractional shortening
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growth/size/body
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• relative to body weight
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cellular
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• increased proliferation of valvar interstitial cells in E15.5 heart valves
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muscle
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• increased ejection fraction and fractional shortening
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll4tm1b(EUCOMM)Hmgu mutation
(1 available);
any
Vgll4 mutation
(24 available)
|
|
Data Sources
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behavior/neurological
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IMPC - HMGU
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation
(6 available)
Vgll4tm1b(EUCOMM)Hmgu mutation
(1 available);
any
Vgll4 mutation
(24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Vgll4 mutation
(24 available)
Yap1tm1.1Fcam mutation
(0 available);
any
Yap1 mutation
(37 available)
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cardiovascular system
N |
• hearts are normal morphology and function with normal valve thickness and cardiomyocyte proliferation and apoptosis rates
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation
(5 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
Vgll4tm1b(EUCOMM)Hmgu mutation
(1 available);
any
Vgll4 mutation
(24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Vgll4 mutation
(24 available)
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cardiovascular system
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• non-cell autonomous, enhanced proliferation of endothelial-derived valvar interstitial cells leading to valve thickening
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Vgll4tm1b(EUCOMM)Hmgu mutation
(1 available);
any
Vgll4 mutation
(24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Vgll4 mutation
(24 available)
|
|
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cardiovascular system
N |
• neonatal and adult mice exhibit normal valves
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation
(6 available)
Vgll4tm1b(EUCOMM)Hmgu mutation
(1 available);
any
Vgll4 mutation
(24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Vgll4 mutation
(24 available)
|
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cardiovascular system
N |
• neonatal mice exhibit normal capillary vessel distribution and endocardium
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• increased cross sectional area
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• prolonged cell proliferation and reduced apoptosis of endothelial-derived valvar interstitial cells
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• relative to body weight
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• severe at 36 weeks of age
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• at P0 and in adult mice
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• at P0 and in adult mice
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• decreased ejection fraction and fractional shortening
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cellular
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• reduced apoptosis of endothelial-derived valvar interstitial cells
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• prolonged cell proliferation of endothelial-derived valvar interstitial cells
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muscle
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• increased cross sectional area
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• decreased ejection fraction and fractional shortening
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growth/size/body
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• relative to body weight
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• severe at 36 weeks of age
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