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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vgll4tm1b(EUCOMM)Hmgu
targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI:6120802
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1b(EUCOMM)Hmgu C57BL/6N-Vgll4tm1b(EUCOMM)Hmgu/Ieg MGI:6263853
hm2
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1b(EUCOMM)Hmgu involves: C57BL/6N * CBA MGI:6360906
ht3
Vgll4tm1b(EUCOMM)Hmgu/Vgll4+ C57BL/6N-Vgll4tm1b(EUCOMM)Hmgu/Ieg MGI:6263852
cn4
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Yap1tm1.1Fcam/Yap1+
Tg(Tek-cre)1Ywa/0
involves: 129S4/SvJae * C57BL/6N * CBA * SJL MGI:6360911
cn5
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Tek-cre)1Ywa/0
involves: 129S6/SvEvTac * C57BL/6NCrl * CBA * SJL MGI:6360909
cn6
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * C57BL/6N * CBA/J * SJL MGI:6360913
cn7
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Tg(Tek-cre)1Ywa/0
involves: C57BL/6N * CBA * SJL MGI:6360907


Genotype
MGI:6263853
hm1
Allelic
Composition
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1b(EUCOMM)Hmgu
Genetic
Background
C57BL/6N-Vgll4tm1b(EUCOMM)Hmgu/Ieg
Cell Lines HEPD0680_7_D07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6360906
hm2
Allelic
Composition
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1b(EUCOMM)Hmgu
Genetic
Background
involves: C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die within 14 weeks of birth

cardiovascular system
N
• at neonatal stages, mitral and tricuspid valves appear normal
• increased proliferation of valvar interstitial cells in E15.5 heart valves
• relative to body weight
• at adult and neonatal stages
• at adult and neonatal stages
• increased velocity and pressure gradient across the aortic valves
• increased ejection fraction and fractional shortening

growth/size/body
• relative to body weight
• from birth

cellular
• increased proliferation of valvar interstitial cells in E15.5 heart valves

muscle
• increased ejection fraction and fractional shortening




Genotype
MGI:6263852
ht3
Allelic
Composition
Vgll4tm1b(EUCOMM)Hmgu/Vgll4+
Genetic
Background
C57BL/6N-Vgll4tm1b(EUCOMM)Hmgu/Ieg
Cell Lines HEPD0680_7_D07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

homeostasis/metabolism




Genotype
MGI:6360911
cn4
Allelic
Composition
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Yap1tm1.1Fcam/Yap1+
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6N * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation (6 available)
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation (0 available); any Vgll4 mutation (24 available)
Yap1tm1.1Fcam mutation (0 available); any Yap1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• hearts are normal morphology and function with normal valve thickness and cardiomyocyte proliferation and apoptosis rates




Genotype
MGI:6360909
cn5
Allelic
Composition
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Tek-cre)1Ywa mutation (6 available)
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation (0 available); any Vgll4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• non-cell autonomous, enhanced proliferation of endothelial-derived valvar interstitial cells leading to valve thickening




Genotype
MGI:6360913
cn6
Allelic
Composition
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: C57BL/6J * C57BL/6N * CBA/J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation (0 available); any Vgll4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• neonatal and adult mice exhibit normal valves




Genotype
MGI:6360907
cn7
Allelic
Composition
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: C57BL/6N * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation (6 available)
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation (0 available); any Vgll4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• neonatal mice exhibit normal capillary vessel distribution and endocardium
• increased cross sectional area
• prolonged cell proliferation and reduced apoptosis of endothelial-derived valvar interstitial cells
• relative to body weight
• severe at 36 weeks of age
• at P0 and in adult mice
• at P0 and in adult mice
• decreased ejection fraction and fractional shortening

cellular
• reduced apoptosis of endothelial-derived valvar interstitial cells
• prolonged cell proliferation of endothelial-derived valvar interstitial cells

muscle
• increased cross sectional area
• decreased ejection fraction and fractional shortening

growth/size/body
• relative to body weight
• severe at 36 weeks of age





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory